Results 71 to 80 of about 2,566,965 (290)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Analytical Investigation of Rupture Phenomena in Sheet Hydro-forming Process by Hemispherical Punch [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2014
Rupture and wrinkling are two prevalent phenomena that happen in hydro-forming process. Many efforts have been made to achieve the upper and lower bounds for the pressure related to rupture and wrinkling of sheet, respectively.
Alireza Naddaf Oskouei, Mohammad Reza Elhami, Iman Karami Fath   +2 more
doaj  

A geometrical upper bound on the inflaton range

Journal of High Energy Physics, 2018
We argue that in type IIB LVS string models, after including the leading order moduli stabilisation effects, the moduli space for the remaining flat directions is compact due the Calabi-Yau Kähler cone conditions. In cosmological applications, this gives
Michele Cicoli, David Ciupke, Christoph Mayrhofer, Pramod Shukla   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Upper bound of holographic entanglement entropy combinations

Journal of High Energy Physics
In this work, we develop a systematic formalism to evaluate the upper bound of a large family of holographic entanglement entropy combinations when fixing n subsystems and fine-tuning one other subsystem.
Xin-Xiang Ju, Ya-Wen Sun, Yang Zhao
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Upper Bounds for Turán Numbers

Journal of Combinatorial Theory, Series A, 1997
The Turán number \(T(n,k,r)\) is the minimum size of a system of \(r\)-subsets of an \(n\)-set such that every \(k\)-subset contains at least one of the members of the system. The paper gives asymptotic upper bounds for these numbers. Constructive upper bounds in case that \(k=2r+1\) have been given by \textit{D. de Caen} et al. [Congr. Numerantium 65,
openaire   +2 more sources

An upper bound on the minimal dispersion [PDF]

Journal of Complexity, 2018
For $\varepsilon\in(0,1/2)$ and a natural number $d\ge 2$, let $N$ be a natural number with \[ N \,\ge\, 2^9\,\log_2(d)\, \left(\frac{\log_2(1/\varepsilon)}{\varepsilon}\right)^2. \] We prove that there is a set of $N$ points in the unit cube $[0,1]^d$, which intersects all axis-parallel boxes with volume $\varepsilon$.
Mario Ullrich, Jan Vybíral
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source