Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Ermeni meselesi ve pek çok konuya ilişkin arşivlerimizde zengin bilgiler bulunmaktadır. Nitekim bu haliyle arşivlerimiz bütün dünya devletlerini yakından ilgilendiren bir hüviyettedir.
Ahmet Halaçoğlu
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Khotyn Uprising was an event that became one of the most striking pages in the history of the region in the XX century. Considerable attention was paid to the study of the history of this issue during the Soviet period, but interpretation of the ...
Tetyana Dubitska
doaj +1 more source
Tensions of colonial punishment: perspectives on recent developments in the study of coercive networks in Asia, Africa and the Caribbean [PDF]
The study of penal practices in colonised parts of Asia, Africa, Latin America, the Indian Ocean and the Caribbean has recently witnessed a significant shift.
Altink +77 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
PRASA OKRESU POWSTANIA WARSZAWSKIEGO. „BIULETYN INFORMACYJNY” I JEGO STRUKTURA GATUNKOWA
The presented paper concerns press in the period of the Warsaw Uprising, especially “Biuletyn Informacyjny”. Polish underground editing movement was the greatest amongst European countries covered by the World War II.
Wioleta Wróbel
doaj +1 more source
Speech by H.E. Amani Abeid Karume former President of Zanzibar on recent developments in North Africa; impact on the Arab World, Africa and the world at large, lessons learned [PDF]
This is the archive of a speech on developments in North Africa given by President Karume of Zanzibar, APC's 7th President in Residence, on March 10 ...
Karume, H.E. Amani Abeid
core +1 more source
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source

