Results 61 to 70 of about 3,377 (180)

Clinical markers for identifying cholinergic deficits in Parkinson's disease [PDF]

, 2015
BackgroundCholinergic projection systems degeneration is associated with dopamine nonresponsive features of Parkinson's disease (PD). Cholinergic deficits are variable in nondemented PD.
Boeve, Bohnen, Bohnen, Bohnen, Bohnen, Bohnen, Bohnen, Bohnen, Braak, Chung, Doty, Doty, Dubois, Goetz, Grimbergen, Hoehn, Hughes, Kotagal, Kotagal, Kotagal, Kotagal, Langston, Lee, Muller, Muller, Muller, Nagatsuka Si, Nasreddine, Shao, Sohn, Svenningsson, Yarnall   +31 more
core   +1 more source

Applying a new version of the Brazilian-Portuguese UPSIT smell test in Brazil [PDF]

, 2010
Standardized olfactory tests are now available to quantitatively assess disorders of olfaction. A Brazilian-Portuguese version of the University of Pennsylvania Smell Identification Test (UPSIT) is currently being developed specifically for the Brazilian
Azevedo, AMS, Barbosa, ER, Doty, RL, Lees, AJ, Ranvaud, R, Silveira-Moriyama, L   +5 more
core  

Spinocerebellar Ataxia Type 2 [PDF]

, 2012
1. Introduction: The autosomal dominant cerebellar ataxias (ADCA) are a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders caused by degeneration of cerebellum and its afferent and efferent connections.
Auburger, Georg, Freund, Hans-Joachim, Rodríguez-Labrada, Roberto, Velázquez-Pérez, Luis   +3 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

High prevalence of olfactory impairment among leprosy patients: A cross-sectional study.

PLoS Neglected Tropical Diseases, 2023
BackgroundThe effect of leprosy on the sense of smell is not yet fully established. Studies that have relied only on patients' perceptions may have under- or over-estimated the change in smell perception.
Rogério Nabor Kondo, Milene Cripa Pizatto de Araújo, Paulo Muller Ramos, Hélio Amante Miot, Marco Aurélio Fornazieri   +4 more
doaj   +1 more source

Development of an International Odor Identification Test for Children: The Universal Sniff Test [PDF]

, 2018
Objective: To assess olfactory function in children and to create and validate an odor identification test to diagnose olfactory dysfunction in children, which we called the Universal Sniff (U-Sniff) test.
Agosin, Eduardo, Altundag, Aytug, Avni, Hadas, Cao Van, Helene, Cornejo, Carlos, de los Santos, Gonzalo, Fishman, Gad, Fragola, Claudio, Guarneros, Marco, Gupta, Neelima, Hudson, Robyn, Hummel, Thomas, Kamel, Reda, Knaapila, Antti, Konstantinidis, Iordanis, Landis, Basile N., Larsson, Maria, Lundström, Johan N., Macchi, Alberto, Mariño-Sánchez, Franklin, Martinec Nováková, Lenka, Mori, Eri, Mullol, Joaquim, Nord, Marie, Parma, Valentina, Philpott, Carl, Propst, Evan J., Rawan, Ahmed, Sandell, Mari, Schriever, Valentin A., Sorokowska, Agnieszka, Sorokowski, Piotr, Sparing-Paschke, Lisa-Marie, Stetzler, Carolin, Valder, Claudia, Vodicka, Jan   +35 more
core   +1 more source

Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health‐related quality of life and posing a safety hazard. Methods WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo ...
Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose   +14 more
wiley   +1 more source

Olfaction in Linked Parkinson’s Disease: Is It Different from Idiopathic Parkinson’s Disease?

Journal of Parkinson’s Disease, 2020
Background: Studies on olfaction in LRRK2 -associated Parkinson’s disease ( LRRK2 -PD) have yielded variable results. The impact of smell dysfunction upon daily life activities have been rarely assessed in PD.
Dolores Vilas, Eduard Tolosa, María Quintana, Claustre Pont-Sunyer, Meritxell Santos, Aina Casellas, Francesc Valldeoriola, Yaroslau Compta, María José Martí, Joaquim Mullol   +9 more
doaj   +1 more source

Parkinson's disease: autoimmunity and neuroinflammation [PDF]

, 2016
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO, CONTE, MICHELA, DE VINCENTIIS, Marco, DE VIRGILIO, ARMANDO, FABBRINI, Giovanni, GALLO, Andrea, GRECO, Antonio, INGHILLERI, Maurizio, RIZZO, MARIA IDA, ROSATO, CHIARA   +9 more
core   +1 more source

Determining the Minimal Clinically Important Difference of the 40‐Item Smell Identification Test in People With Cystic Fibrosis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) are highly prevalent among people with cystic fibrosis (PwCF) and negatively impact quality of life. The 40‐item Smell Identification Test (SIT) is widely used to assess psychophysical olfaction, but a CF‐specific minimal clinically important difference (MCID) has not been ...
Eugene Oh, Jessa E. Miller, Michelle J. Lee, Anna Zemke, David Baraghoshi, Matthew J. Strand, Jeremiah A. Alt, Todd E. Bodner, Michael Chang, Naweed I. Chowdhury, Patricia H. Eshaghian, Anne E. Getz, Jennifer L. Goralski, David A. Gudis, Peter H. Hwang, Ashoke Khanwalkar, Adam J. Kimple, Jivianne T. Lee, Douglas A. Li, Jess C. Mace, Jayakar V. Nayak, Jonathan B. Overdevest, Zara Patel, Daniella K. Safatian, Rodney J. Schlosser, Brent Senior, Amanda L. Stapleton, Timothy L. Smith, Zachary M. Soler, Jeffrey D. Suh, Grant A. Turner, Marilene B. Wang, Milene T. Saavedra, Jennifer L. Taylor‐Cousar, Daniel M. Beswick   +34 more
wiley   +1 more source