Results 151 to 160 of about 165,169 (375)

Impact of Chelation on Reactivity and Cytotoxicity of Hemilabile Biphenyl Gold(III) N‐Heterocyclic Carbene Complexes

ChemMedChem, EarlyView.
An array of eight pairs of biphenyl gold(III) complexes comprising NHC–pyridine ligands having a hemilabile character in vitro displays antiproliferative activity toward human cells in the low micromolar range which is exclusively due to their neutral open form according to speciation studies.
Tom Lacoma, Jérémy Forté, Régina Maruchenko, Romain Morichon, Michèle Salmain, Joëlle Sobczak‐Thépot, Benoît Bertrand   +6 more
wiley   +1 more source

KHẢO SÁT THÀNH PHẦN HÓA HỌC CỦA TRÁI KHỔ QUA (MOMORDICA CHARANTIA L.)

Tạp chí Khoa học Đại học Cần Thơ, 2011
Từ trái Khổ qua, hai chất: uracil (chất I, Hình 1) và momordicoside K (chất II, Hình 2) đã được cô lập từ cao ethyl acetate. Hai chất này được xác định bằng các phương pháp phổ hiện đại và so sánh với tài liệu đã công bố.
Ngô Hải Đăng, Nguyễn Ngọc Hạnh, Phùng Văn Trung   +2 more
doaj  

Thymine and Uracil Metabolism in the Epidermis*

Journal of Investigative Dermatology, 1967
As compared with the viable epidermis, the stratum corneum contains very small amounts of both DNA and RNA (1, 2, 3, 4). This decrease in nucleic acid content is correlated with the disappearance of nuclei and ribosomes which occurs at the junction of the granular layer and stratum corneum.
openaire   +3 more sources

Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy

ChemPlusChem, EarlyView.
Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

Multiple Hydrogen‐Bond Cross‐Linking Solid–Solid Phase Change Materials for Batteries’ Thermal Management

EcoEnergy, EarlyView.
Multiple hydrogen‐bond cross‐linking solid–solid phase change materials. ABSTRACT Solid–solid phase change materials usually suffer from the challenges of low thermal storage capacity and poor mechanical strength in thermal management applications. Additionally, solid–solid phase change materials are often prepared by a chemical cross‐linking strategy,
Xuemei Diao, Peng Wang, Yang Li, Xiao Chen   +3 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Process of Infection with Bacteriophage φX174 XXXIII. Templates for the Synthesis of Single-Stranded Deoxyribonucleic Acid [PDF]

, 1970
The origin of the templates for the synthesis of {varphi}X174 progeny single-stranded deoxyribonucleic acid was studied by means of the mutagenic activity associated with the decay of incorporated 3H-labeled 5-cytosine.
Funk, Fred, Sinsheimer, Robert L.
core  

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Identification of Hot and Cold Regions for Mutagenesis in the Escherichia coli tdk Gene: A Catalog of Mutational Sites

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT We constructed a catalog of mutational sites in the tdk gene of Escherichia coli that consists of 378 different base pair substitutions at 245 different sites (base pairs). This allows us to examine the tendency of different sub‐regions of the gene to be more or less prone to mutations when compared with other sub‐regions.
Katherine Douglas, Dana Sorensen, Arnav Saud, Ananya Sridharan, Mallika Mathew, Jyotsna Hiranandani, Ava Gonick, Courtney Young, Kelly Nguyen, Nhu Phi, Jeffrey H. Miller   +10 more
wiley   +1 more source

Nanoplatform‐Enabled Genetic Interventions for Central Nervous System Disorders: Advances in Delivery Strategies and Therapeutic Potential

Advanced Genetics, EarlyView.
This review provides a detailed description of gene mutations and epigenetic mechanisms in central nervous system (CNS) disease, strategies for gene therapy, challenges for CNS gene therapy and gene‐drug nanocarriers. This review also summarizes the applications of nanogenetic therapy platforms in CNS diseases (brain tumors, neurodegenerative diseases,
Fuming Liang, Shizhen Cui, Jing Yang, Zhaohui He, Ling Zhu   +4 more
wiley   +1 more source