Results 181 to 190 of about 14,080 (252)

Comparing the Performance of Double‐Stranded and Single‐Stranded DNA Libraries for Ancient Oral Microbiome Reconstruction

Molecular Ecology Resources, Volume 26, Issue 7, October 2026.
ABSTRACT DNA library construction methods can affect the recovery of ancient DNA, thus influencing downstream analyses. While single‐stranded library preparation (ssLib) has been shown to outperform double‐stranded (dsLib) for highly degraded vertebrate host DNA, especially for samples older than 40,000 years, few studies have examined how library ...
Keri Burge, Irina M. Velsko, Domingo C. Salazar‐García, María Haber Uriarte, Joaquín Lomba Maurandi, Christina Warinner   +5 more
wiley   +1 more source

International Dermoscopy Society consensus recommendations for the management of lentigo maligna

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 10, Page 1600-1617, October 2026.
Lentigo maligna (LM) poses diagnostic and therapeutic challenges amid rising incidence and limited high‐quality evidence. This international expert consensus provides pragmatic, evidence‐based and expertise‐informed guidance on LM diagnosis and management.
Ana‐Maria Forsea, Riccardo Pampena, Bengu Nisa Akay, Zoe Apalla, Giuseppe Argenziano, Giulia Briatico, Ralph Braun, Horacio Cabo, Raul Cabrera, Cristina Carrera, Elisa Cinotti, Claudio Conforti, Enzo Errichetti, Gerardo Ferrara, Roberta Giuffrida, Stefania Guida, Pascale Guitera, Allan C. Halpern, Stephen Heyes, Rainer Hofmann‐Wellenhof, Angela M. Hong, Natalia Jaimes, Raimonds Karls, Harald Kittler, Teresa Kränke, Konstantinos Liopyris, Jie Liu, Caterina Longo, Josep Malvehy, Ashfaq A. Marghoob, Hoda Moneib, David Moreno Ramirez, Elvira Moscarella, Eduardo Nagore, Cristian Navarrete‐Dechent, John Paoli, Giovanni Pellacani, Ketty Peris, Susana Puig, Cliff Rosendahl, Lidia Rudnicka, Ahmed Sadek, Philippe Saiag, Gabriel Salerni, Alon Scope, Hans Peter Soyer, Michela V. Starace, Wilhelm Stolz, David L. Swanson, Luc Thomas, Philipp Tschandl, Iris Zalaudek, Aimilios Lallas   +52 more
wiley   +1 more source

Au(I) Complex With an Abnormal Carbene Ligand Shows Anti‐Kasha Dual Photoluminescence Emission

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Incorporation of an abnormal N‐heterocyclic carbene into a heteroleptic linear Au(I) complex induces anti‐Kasha dual emission responsive to biologically relevant phenyl sulfate. ABSTRACT We report the first photoactive linear Au(I) complex with an abnormal N‐heterocyclic carbene (aNHC) ligand, Au(aIm)(Cz).
Natesan Mannangatti Rajendran, Seung Beom Cheon, Jungbin Shin, Ye Bin Jang, Taeyoon Kim, Youngmin You   +5 more
wiley   +2 more sources

Identification of Critical Amino Acid Residues Required for the Polar Localization of a Rice Manganese Transporter

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5340-5351, October 2026.
ABSTRACT Rice has developed an efficient system for manganese (Mn) uptake, mediated by two distinct transporters, OsNramp5 and OsMTP9. These transporters exhibit polar localization at the root exodermis and endodermis; however, the mechanisms underlying their polar localization and their role in Mn uptake remain unclear.
Noriyuki Konishi, Jian Feng Ma
wiley   +1 more source

Metabolomic Analysis Reveals Structural Diversity of Pectic Polysaccharides From Prunus persica (L.) Batsch and Their Relationship With Purees Characteristics

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5425-5439, October 2026.
ABSTRACT To clarify how pectin heterogeneity relates to puree quality, this study investigated associations among pectin fractions, metabolite profiles, and physicochemical properties of peach purees from 20 cultivars with distinct viscosity, turbidity, and colour.
Meng Liu, Xuan Liu, Shaojie Fu, Qianhui Yang, Christophe Blecker, Jinfeng Bi   +5 more
wiley   +1 more source

A 4′‐Thioribouridine Modification Mimics 2′‐O‐Methoxyethyl in ASO‐Like 20‐Mers Targeting PTEN Knockdown

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
A 4′‐thiouridine phosphoramidite was prepared and site‐selectively incorporated into PTEN‐targeting gapmer ASOs. Flank‐modified gapmers with defined phosphorothioate linkage patterns maintained potent target knockdown under transfection and gymnotic delivery, matching 2′‐O‐methoxyethyl comparators and highlighting 4′‐thioribose as a valuable motif for ...
Joanna E. Parkes, Caecilie M. M. Benckendorff, Anna L. Malinowska, Jacob Roberts, Harley L. Huynh, Sritama Bose, Loïc M. Cochard, Aisling Ní Cheallaigh, Sarah L. Lovelock, Peter L. Oliver, Gavin J. Miller   +10 more
wiley   +1 more source

Sodium Channel Blockers Demonstrate Binding Affinity for the Tandem Tudor Domain of the Epigenetic Hub UHRF1

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis, Mariangela Giannouli, Ifigeneia Akrani, Anthi Panara, Eleni Katalagarianou, Kyriaki Degaita, Maria Giahou, Konstantina Kyriakou, Maria Routsi, Panagiota Efstathia Nikolaou, Evangelia Tsitsou, Aggeliki Tsoka, Constantinos C. Vorgias, Emmanuel Mikros, Evangelos Gikas, Eleni K. Efthimiadou, Vassilios Myrianthopoulos   +16 more
wiley   +1 more source

A Fast and Parallelized Procedure for Checking Molecular Dynamics 3D Structure

Journal of Computational Chemistry, Volume 47, Issue 23, September 5, 2026.
Common structural issues such as atomic overlaps, abnormal bond lengths, and ring‐bond intersections can be rapidly detected in the pairlist‐enabled and parallelized “checkstructure” command from CPPTRAJ, for example, the ~256 k atom 5a9z system can be checked in less than 2 s using 16 threads.
Daniel R. Roe, Bernard R. Brooks
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, Volume 16, Issue 9, Page 1669-1690, September 2026.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, Volume 16, Issue 9, Page 1752-1765, September 2026.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source