Results 191 to 200 of about 86,414 (313)

CRISPR-Cas9-mediated targeted gene deletion in <i>Aspergillus calidoustus</i>, a non-model environmental mold. [PDF]

Microbiol Spectr
Hollomon JM, Dahlstrom KM.
europepmc   +1 more source

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Anti-Toxoplasma activity of NBMPR is mediated through the inhibition of nucleoside and nucleobase transporters. [PDF]

Parasitol Res
Pan M, Tang SQ, Ge CC, Fan SJ, He HX, Bian MM, Shen B, Huang SY.   +7 more
europepmc   +1 more source

Electroacupuncture Ameliorates Cognitive Impairment in Vascular Dementia Rats: Potential Involvement of the Astrocyte–Synapse Axis

Brain and Behavior, Volume 16, Issue 6, June 2026.
Electroacupuncture significantly ameliorates cognitive impairment and synaptic damage in vascular dementia rats, showing specific advantages over nimodipine. These neuroprotective effects are closely associated with modulating the astrocyte–synapse axis to suppress neuroinflammation and enhance neurotrophic support.
Sijing Guo, Qian Liu, Shihao Lin, Taotao Zhou, Qin Hu, Zhongsheng Tang   +5 more
wiley   +1 more source

Development of Biphenyl-Substituted Uracil-Based Hydroxamic Acids (UBHAs) as Potent HDAC Inhibitors with Pro-Apoptotic Activity in Leukemia and Prostate Cancer Cells. [PDF]

J Med Chem
Fiorentino F, Bontempi G, Michetti F, Pecci V, Fabbrizi E, Passeri D, Corsetti L, Farini V, Casano F, Gioiello A, Di Sotto A, Pellicciari R, Del Bufalo D, Trisciuoglio D, Nanni S, Strippoli R, Mai A, Rotili D.   +17 more
europepmc   +1 more source

Optimizing Outcomes in Elderly HNSCC: Efficacy of UFT Metronomic Therapy

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Introduction Head and neck squamous cell carcinoma (HNSCC) remains a significant clinical challenge, especially in elderly patients with advanced‐stage disease and multiple comorbidities. Metronomic chemotherapy with oral tegafur‐uracil (UFT) offers a low‐toxicity maintenance option that may improve outcomes.
Hsu‐Lin Lee, Po‐Huang Chen, Yu‐Guang Chen, Jia‐Hong Chen, Tzu‐Chuan Huang, Ching‐Liang Ho, Ren‐Hua Ye   +6 more
wiley   +1 more source

Anti-Neuroinflammatory Effects of a Representative Low-Molecular-Weight Component Isolated from <i>Codium fragile</i> Through Inhibition of the NF-κB Pathway in Microglia and Macrophage Cells. [PDF]

Mar Drugs
Lee G, Jin Y, Lee SA, Lee SY, Lee H, Nan Z, Yoon CS, Lee DS.   +7 more
europepmc   +1 more source

Functionalizing Nucleobases With Boronic Acids and Boronic Acid Esters: Thymine Derivatives and Their Dioxazaborocane Chemistry

ChemPlusChem, Volume 91, Issue 6, June 2026.
Boronic acid‐substituted thymine derivatives are well established and exhibit a range of biological activities. In contrast, the corresponding boronic acid esters and dioxazaborocane analogs remain largely unexplored. Herein, we report the synthesis and structural characterization of thymine derivatives bearing boronic acid, boronic acid ester, and ...
Tabea Lenz, Marcus Layh, Marian Hebenbrock   +2 more
wiley   +1 more source

B cell receptor stimulation inhibits class switch recombination through elevated DNA repair. [PDF]

DNA Repair (Amst)
Maul RW, McFleder RL, Cao Z, Norton DD, Ridani J, Barbulescu P, Martin A, Di Noia JM, Gearhart PJ.   +8 more
europepmc   +1 more source

The Great Bustard (Otis tarda) and Common Crane (Grus grus) Utilize Food Resources via Gut Microbiota Remodeling During Wintering in the Yellow River Wetlands in Ordos City, Inner Mongolia, China

Ecology and Evolution, Volume 16, Issue 6, June 2026.
This study detected the diet and gut microbiota of great bustards and common cranes in the wintering duration in the Yellow River Wetlands of Inner Mongolia using high‐throughput sequencing technology. This study indirectly indicated that great bustards and common cranes are well‐adapted to the environment of the Yellow River Wetlands during the ...
Li Gao, Haitao Fang, Hongda Pei, Junlan Li, Li Liu   +4 more
wiley   +1 more source