Results 271 to 280 of about 165,169 (375)

Optimisation of Heated Electrospray Ionisation Parameters to Minimise In‐Source Generated Impurities in the Analysis of Oligonucleotide Therapeutics

Rapid Communications in Mass Spectrometry, Volume 39, Issue 13, 15 July 2025.
ABSTRACT Rationale Oligonucleotides have emerged as an important new class of therapeutic. Due to their structural complexity, this presents significant challenges for the development of analytical methods to characterise and determine their impurity profile.
Mollie A. Glenister, Ulrik Mistarz, Ken Cook, James L. Stephenson, Mark J. Dickman   +4 more
wiley   +1 more source

Gamma Ray-induced Mutations in pyrEF Genes in Frankia casuarinae Strain CcI3. [PDF]

Microbes Environ
Kucho KI, Han O, Yunoki M.
europepmc   +1 more source

Photoreductive Cyclization of 5-Nitro-6-styryl(or anilino)uracil Derivatives to Pyrrolo[3,2-d]pyrimidine and Alloxazine Derivatives

, 1976
S. Senda, Kosaku Hirota, Mikio Takahashi
openalex   +1 more source

Adjuvant treatment with Capecitabine in patients who received orthotopic liver transplantation with incidental diagnosis of intrahepatic cholangiocarcinoma. Implications on DPYD polymorphisms assessment: report of two cases and review of the literature. [PDF]

Cancer Chemother Pharmacol
Liguori C, Magi S, Mandolesi A, Agostini A, Svegliati-Baroni G, Benedetti Cacciaguerra A, Parisi A, Tiberi E, Vivarelli M, Giovagnoni A, Goteri G, Castaldo P, Berardi R, Giampieri R.   +13 more
europepmc   +1 more source

Hybridization and Asymmetrical Introgression Between the Vulnerable Gray‐Headed Chickadee and a More Abundant Congener, the Boreal Chickadee: Implications for Conservation

Ecology and Evolution, Volume 15, Issue 7, July 2025.
We assess genetic evidence of hybridization between gray‐headed chickadees and boreal chickadees using mitochondrial DNA and nuclear DNA sequencing of individuals from historical and contemporary time periods. We detected two early‐generation hybrids among the historical boreal chickadee samples and none within the contemporary boreal chickadee samples
Matthew R. Armstrong, Robert E. Wilson, James A. Johnson, Travis L. Booms, Callie F. Gesmundo, Zachary M. Pohlen, Paul B. Leonard, Sarah A. Sonsthagen   +7 more
wiley   +1 more source

CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity. [PDF]

Proc Natl Acad Sci U S A
Rodriguez MM, Chatterjee D, Guerry J, Patenaude AM, Cohen CCH, Bois T, Larouche A, Ferreira SR, Bertomeu T, Chatr-Aryamontri A, Zhang L, Mader S, Nislow C, St-Jean G, Guindon Y, Zahn A, Di Noia JM.   +16 more
europepmc   +1 more source

The Role of Methylation as an Epigenetic Marker in HPV‐Related Oral Lesions

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT Oral and oropharyngeal cancers, caused by persistent human papillomavirus (HPV), have recently increased. Diagnostic methods often fail to assess precancerous lesion risk, delaying oral cancer diagnosis. New molecular biomarkers, particularly DNA methylation, are sought to better stratify patients' risk.
Buttà Michela, Serra Nicola, Sucato Arianna, Cabibi Daniela, Campisi Giuseppina, Panzarella Vera, Alfedi Giulia, Pistoia Daniela, Capra Giuseppina   +8 more
wiley   +1 more source

UFUR maintenance therapy significantly improves survival in locally advanced head and neck squamous cell carcinoma following definitive chemoradiotherapy. [PDF]

Cancer Cell Int
Hsieh JC, Lien MY, Chang PH, Wang HM, Yeh KY, Ho CL, Hsieh CY, Hsieh MC, Chen JH.   +8 more
europepmc   +1 more source

The Enzymatic Conversion of 5-Formyluracil to Uracil 5-Carboxylic Acid

, 1970
Mutsumi Watanabe, R.P. McCroskey, M.T. Abbott   +2 more
openalex   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source