Results 261 to 270 of about 86,414 (313)
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The Photochemistry of Uracil: A Reinvestigation
Photochemistry and Photobiology, 2010AbstractResults from a re‐examination of the photochemical reactions undergone by uracil (Ura) are presented. Irradiation of Ura in frozen aqueous solution at −78.5°C produces two diastereomeric (6‐4) products, namely the cis and trans isomers of 5‐hydroxy‐6‐4′‐(pyrimidin‐2′‐one)‐5,6‐dihydrouracil.
Martin D, Shetlar, Vladimir J, Basus
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European Journal of Medicinal Chemistry, 2015
This review article is an effort to summarize recent developments in researches providing uracil derivatives with promising biological potential. This article also aims to discuss potential future directions on the development of more potent and specific uracil analogues for various biological targets. Uracils are considered as privileged structures in
Aleksandra, Pałasz, Dariusz, Cież
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This review article is an effort to summarize recent developments in researches providing uracil derivatives with promising biological potential. This article also aims to discuss potential future directions on the development of more potent and specific uracil analogues for various biological targets. Uracils are considered as privileged structures in
Aleksandra, Pałasz, Dariusz, Cież
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Drugs & Aging, 2001
Tegafur is a prodrug of the antineoplastic agent fluorouracil, and is administered in a 1:4 molar ratio with the fluorouracil modulator uracil. Oral tegafur/uracil 300 mg/m(2)/day plus calcium folinate 75 or 90 mg/day for 28 days every 35 days was as effective as intravenous (IV) fluorouracil 425 mg/m(2)/day plus folinic acid 20 mg/m(2)/day for 5 days ...
K, Wellington, K L, Goa
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Tegafur is a prodrug of the antineoplastic agent fluorouracil, and is administered in a 1:4 molar ratio with the fluorouracil modulator uracil. Oral tegafur/uracil 300 mg/m(2)/day plus calcium folinate 75 or 90 mg/day for 28 days every 35 days was as effective as intravenous (IV) fluorouracil 425 mg/m(2)/day plus folinic acid 20 mg/m(2)/day for 5 days ...
K, Wellington, K L, Goa
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Science, 1962
Explorations in the pyrimidine series have led to the discovery of highly active herbicides, of which 3-butyl-6-methyluracil and 5-bromo-3-isopropyl-6-methyluracil are examples.
H C, BUCHA +4 more
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Explorations in the pyrimidine series have led to the discovery of highly active herbicides, of which 3-butyl-6-methyluracil and 5-bromo-3-isopropyl-6-methyluracil are examples.
H C, BUCHA +4 more
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The Synthesis of Uracils as Anticonvulsants*
Journal of the American Pharmaceutical Association (Scientific ed.), 1955Abstract A convenient laboratory synthesis has been devised by which a series of new 5‐alkyluracils has been prepared for evaluation as anti‐convulsants. Certain other 5‐substituted uracils and their N,N‐dimethyl derivatives, and related compounds, have also been synthesized.
J H, BURCKHALTER, H C, SCARBOROUGH
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PHOTOSENSITIZED DIMERIZATION OF URACIL
Photochemistry and Photobiology, 1972Abstract— The four isomeric dimers of uracil were isolated from photochemical reactions which were sensitized by acetone. Product analyses, made on the basis of the chemical properties of the compounds, showed that the h, h dimers predominate. Infrared and mass spectra for the dimers are here presented as well as nuclear magnetic resonance data.
B H, Jennings +2 more
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Stable Triplet of Uracil−Uracil Basepairs in a Small Antisense RNA
Journal of the American Chemical Society, 2005The interaction between ant (antirepressor) mRNA and its antisense RNA, sar (small antisense RNA), is important in regulation of the development of bacteriophage P22. Sar is 68-69 nucleotides in length and is believed to consist of two hairpin structures separated by a small inter-hairpin region, followed by a short 3' tail [Schaefer and McClure RNA ...
Yiping, Zhan, Gordon S, Rule
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ALTERATION OF URACIL-DNA GLYCOSYLASE ACTIVITY BY URACIL DIMERS IN DNA
Photochemistry and Photobiology, 1981— The effects of UV irradiation on double-stranded PBS-2 phage DNA, which contains uracil in place of thymine, were studied. Irradiation by 254 nm light, or by 313 nm light in the presence of the triplet sensitizer acetophenone, resulted in production of uracil-containing pyrimidine photodimers. DNA chain breaks were also produced under both conditions.
N J, Duker, W A, Davies, D M, Hart
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Antibacterial Properties of Silver Chelates of Uracil and Uracil Derivatives in vitro
Chemotherapy, 2009Silver chelates of uracil and uracil derivatives yield biologically active compounds effective against several strains of bacteria including P. aeruginosa with minimal toxicity to the host in vitro. Toxicity studies conducted in tissue culture revealed comparative toxicity equal to that of the control containing penicillin and streptomycin.
M S, Wysor, R E, Zollinhofer
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Reaction of Bromine with Uracils
Nature, 1957SOME interesting observations on the reaction of bromine with pyrimidine compounds were recently reported by Cohn1. Since 1907, when Wheeler and Johnson2 first observed the coloured reaction product obtained by the action of bromine with uracil or cytosine and isolated the intermediate, the bromine reaction has been utilized for structural ...
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