Results 281 to 290 of about 165,169 (375)

A multicenter retrospective study evaluating the effect of proton pump inhibitors on adjuvant tegafur-uracil/leucovorin efficacy for stage II-III colorectal cancer. [PDF]

open access: yesSci Rep
Takahashi M   +17 more
europepmc   +1 more source

Overexpression of Transketolase Relieves xylA Repression and Enhances Xylose Utilization in Saccharomyces cerevisiae During Mixed Sugar Fermentation

open access: yesGCB Bioenergy, Volume 17, Issue 7, July 2025.
To overcome the bottleneck of inefficient xylose utilization in lignocellulosic bioethanol production, we constructed a recombinant Saccharomyces cerevisiae strain (INVSc‐xylA‐Xltr1p‐TKL1) by overexpressing the transketolase gene TKL1. This engineering strategy significantly enhanced xylose consumption by 33%, upregulated xylose isomerase (xylA ...
Si Xu   +5 more
wiley   +1 more source

Prevalence and Whole Genome Sequence Analysis of Mycoplasma bovis Isolates From Bulk Tank Milk of Dairy Farms in Tennessee, USA

open access: yesJournal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Mycoplasma bovis mastitis is an important disease of dairy cows that causes substantial economic losses. However, its prevalence in different states in the United States (US), including Tennessee, is not well known. Furthermore, recent studies showed a high prevalence of bovine hemotropic mycoplasmas in US dairy farms.
Aga E. Gelgie   +5 more
wiley   +1 more source

Multiple transitions to high l‐DOPA 4,5‐dioxygenase activity reveal molecular pathways to convergent betalain pigmentation in Caryophyllales

open access: yesNew Phytologist, Volume 247, Issue 1, Page 341-357, July 2025.
Summary Many specialized metabolic pathways have evolved convergently in plants, but distinguishing multiple origins from alternative evolutionary scenarios can be difficult. Here, we explore the evolution of l‐3,4‐dihydroxyphenylalanine (l‐DOPA) 4,5‐dioxygenase (DODA) enzymes to better resolve the convergent evolution of the betalain biosynthetic ...
Nathanael Walker‐Hale   +2 more
wiley   +1 more source

A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA Damage

open access: yesAngewandte Chemie, Volume 137, Issue 24, June 10, 2025.
This work advances methodology by addressing challenges in mimicking the complex in vivo spatial relationships of histone acetylation and DNA damage. The combination of an abiotic/enzymatic hybrid catalyst system (ABEHCS) and the plug‐and‐play method has constituted a versatile platform to construct nucleosome arrays with precise histone acetylation ...
Ziyun Liu   +6 more
wiley   +2 more sources

Trafficking of the telomerase RNA using a novel genetic approach. [PDF]

open access: yesPLoS One
Day JK   +8 more
europepmc   +1 more source

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