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DNA hairpin base-flipping dynamics drives APOBEC3A recognition and selectivity.
Phys Chem Chem PhysHix MA +3 more
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Enzymic determination of uracil nucleotides in tissues.
Analytical Biochemistry, 1970Abstract An enzymic assay for the sequential determination of UDP-glucose, UDP-galactose, UTP, UDP, and 5′-UMP in tissues is described. Two moles of NAD are reduced per mole of uracil nucleotide by use of UDPG dehydrogenase as indicator enzyme. The procedure is highly specific for the measurement of uridine 5′-phosphates.
D. Keppler, J. Rudigier, K. Decker
semanticscholar +3 more sources
P2 receptors activated by uracil nucleotides--an update.
Current Medicinal Chemistry, 2006Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors (GPCRs) of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y2, P2Y4, P2Y6 and P2Y14. P2Y2 and P2Y4 receptors are activated by UTP (the P2Y2, and the rat
A. Brunschweiger, C. Müller
semanticscholar +3 more sources
Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation.
Biochemical Pharmacology, 2008Uracil nucleotides (i.e., UTP and UDP) have been known for years as fundamental intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether represent key building blocks for nucleic acid synthesis. In addition, their sugar conjugates (i.e., UDP-glucose and UDP-galactose) enter in several biochemical routes, for example ...
D. Lecca, S. Ceruti
semanticscholar +4 more sources
Journal of the Chemical Society, Chemical Communications, 1984
Unprotected uracil nucleotides and nucleosides are converted into 5-formyluracil derivatives using a palladium(II) coupling reaction followed by oxidation of the intermediate styryl derivative.
J. Park +4 more
semanticscholar +2 more sources
Unprotected uracil nucleotides and nucleosides are converted into 5-formyluracil derivatives using a palladium(II) coupling reaction followed by oxidation of the intermediate styryl derivative.
J. Park +4 more
semanticscholar +2 more sources
Receptors responsive to extracellular uracil nucleotides
Drug Development Research, 1998The cloning of P2Y 4 and P2Y 3 (chicken) / P2Y 6 (rat, human) receptors has been the ultimate proof that receptors for pyrimidine nucleotides exist. However, on the basis of their structure these receptors do not constitute a family of their own but belong to the P2Y family, which thus encompasses selective purinoceptors (P2Y 1 , P2Y 11 ), nucleotide
D. Communi +4 more
semanticscholar +2 more sources
Interaction of the retinal G-protein transducin with uracil nucleotides.
Biochemical and Biophysical Research Communications, 1999Little is known about the interaction of pyrimidine nucleotides with G-proteins. Here we report that under experimental conditions that exclude transphosphorylation reactions, nucleoside 5'-triphosphates inhibited transducin-catalyzed GTP hydrolysis in the order of potency guanosine 5'-[gamma-thio]triphosphate > GTP > guanosine 5'-[beta,gamma-imido ...
J. F. Klinker, R. Seifert
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Effects of galactose on human leukocyte uracil nucleotides
International Journal of Biochemistry, 1975Abstract 1. 1. Uracil nucleotide contents of human leukocytes were determined by enzymatic analysis. The labelling pattern of uracil nucleotides was studied after incubation of the cells in the presence of [ 14 C]uridine followed by separation of the labelled nucleotides by paper chromatography. 2. 2. A depression of UTP, UDP, and UDP-glucose
J. Forster, D. Keppler
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Glomerular uracil nucleotide synthesis
American Journal of Physiology-Renal Physiology, 1988The biosynthesis of basement membrane material requires the sugar derivatives of uridine 5'-triphosphate (UTP) for protein glycosylation. Uridine and orotate utilization for the biosynthesis of uracil ribonucleotides was studied in isolated rat glomeruli incubated in vitro. At a 1 microM concentration total orotate utilization was 9.6 +/- 1.8 pmol.min-
P, Cortes, F, Dumler, N W, Levin
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Acidity of a Nucleotide Base: Uracil
The Journal of Physical Chemistry A, 2004Experiment and calculations are used to show that the gas-phase acidity of uracil is comparable to that of HCl. The gas-phase acidity of uracil (denoted here by U) was bracketed by proton-transfer measurements involving Uand various reference acids (denoted here by A) of known gas-phase acidity.
Thomas M. Miller +3 more
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