Results 201 to 210 of about 26,862 (228)
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Recognition of an Unnatural Difluorophenyl Nucleotide by Uracil DNA Glycosylase
Biochemistry, 2004The DNA repair enzyme uracil DNA glycosylase (UDG) utilizes base flipping to recognize and remove unwanted uracil bases from the genome but does not react with its structural congener, thymine, which differs by a single methyl group. Two factors that determine whether an enzyme flips a base from the duplex are its shape and hydrogen bonding properties.
Yu Lin, Jiang +8 more
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Interaction of the Retinal G-Protein Transducin with Uracil Nucleotides
Biochemical and Biophysical Research Communications, 1999Little is known about the interaction of pyrimidine nucleotides with G-proteins. Here we report that under experimental conditions that exclude transphosphorylation reactions, nucleoside 5'-triphosphates inhibited transducin-catalyzed GTP hydrolysis in the order of potency guanosine 5'-[gamma-thio]triphosphate > GTP > guanosine 5'-[beta,gamma-imido ...
J F, Klinker, R, Seifert
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Palladium-catalyzed coupling reactions of uracil nucleosides and nucleotides
Journal of the American Chemical Society, 1980Mathias P Mertes
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Synthesis of 5-styryl derivatives of uracil nucleosides and nucleotides.
Tetrahedron Letters, 1979Abstract Uracil nucleosides and nucleotides undergo a palladium catalyzed coupling reaction with styrenes to yield the respective 5-substituted derivatives.
Mathias P Mertes
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Nature Structural & Molecular Biology, 1995
The Bacillus subtilis bacteriophages PBS-1 and PBS-2 protect their uracil-containing DNA by expressing an inhibitor protein (UGI) which inactivates the host uracil-DNA glycosylase (UDGase) base-excision repair enzyme. Also, PBS1/2 UGI efficiently inactivates UDGases from other biological sources, including the enzyme from herpes simplex virus type-1 ...
R, Savva, L H, Pearl
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The Bacillus subtilis bacteriophages PBS-1 and PBS-2 protect their uracil-containing DNA by expressing an inhibitor protein (UGI) which inactivates the host uracil-DNA glycosylase (UDGase) base-excision repair enzyme. Also, PBS1/2 UGI efficiently inactivates UDGases from other biological sources, including the enzyme from herpes simplex virus type-1 ...
R, Savva, L H, Pearl
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Triplet state studies of the nucleoside and nucleotide derivatives of uracil and thymine
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972Abstract Transient absorbing species due to the triplet states of uridine, 5′-uridylic acid, thymidine and 5′-thymidylic acid have been studied by flash photolysis and compared with those of the triplet states of uracil and thymine. These transients are quenched by oxygen and by their ground states with bimolecular rate constants of 6 · 10 8 , 5 · 10
D W, Whillans, H E, Johns
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Glomerular uracil nucleotide synthesis: effects of diabetes and protein intake
American Journal of Physiology-Renal Physiology, 1988The biosynthesis of uridine 5'-triphosphate (UTP), uridine 5'-diphosphohexoses, and 5'-diphosphohexosamines (UDP-sugars) was studied in isolated rat glomeruli 48 h after streptozotocin-induced diabetes. Compared with control, diabetic glomeruli demonstrated an increase in the following: exogenous orotate utilization, orotate incorporation into UTP and
P, Cortes +3 more
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in vivo RNA structural probing of guanine and uracil nucleotides in yeast
2022Abstract RNAs have critical catalytic or regulatory functions in the cell and play significant roles in many steps of gene expression regulation. RNA structure can be essential for its cellular function. Therefore, methods to investigate the structure of RNA in vivo are of great importance for understanding the role ...
Kevin Xiao +2 more
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Canadian Journal of Chemistry, 1973
Proton magnetic resonance data for uridine and uridine-5′-monophosphate, and the corresponding 6-azauracil analogs, are presented and discussed in terms of their overall three dimensional conformations in aqueous solution. The data reveal a destabilizing influence of the 6-aza base upon the gog and g′–g′ conformation of the ribose phosphate moiety.
Donald J. Wood +3 more
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Proton magnetic resonance data for uridine and uridine-5′-monophosphate, and the corresponding 6-azauracil analogs, are presented and discussed in terms of their overall three dimensional conformations in aqueous solution. The data reveal a destabilizing influence of the 6-aza base upon the gog and g′–g′ conformation of the ribose phosphate moiety.
Donald J. Wood +3 more
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