Results 191 to 200 of about 49,133 (225)

Recognition of an Unnatural Difluorophenyl Nucleotide by Uracil DNA Glycosylase

Biochemistry, 2004
The DNA repair enzyme uracil DNA glycosylase (UDG) utilizes base flipping to recognize and remove unwanted uracil bases from the genome but does not react with its structural congener, thymine, which differs by a single methyl group. Two factors that determine whether an enzyme flips a base from the duplex are its shape and hydrogen bonding properties.
Yu Lin, Jiang, Lynda M, McDowell, Barbara, Poliks, Daniel R, Studelska, Chunyang, Cao, Gregory S, Potter, Jacob, Schaefer, Fenhong, Song, James T, Stivers   +8 more
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Glomerular uracil nucleotide synthesis: effects of diabetes and protein intake

American Journal of Physiology-Renal Physiology, 1988
The biosynthesis of uridine 5'-triphosphate (UTP), uridine 5'-diphosphohexoses, and 5'-diphosphohexosamines (UDP-sugars) was studied in isolated rat glomeruli 48 h after streptozotocin-induced diabetes. Compared with control, diabetic glomeruli demonstrated an increase in the following: exogenous orotate utilization, orotate incorporation into UTP and
P, Cortes, F, Dumler, D L, Paielli, N W, Levin   +3 more
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Interaction of the Retinal G-Protein Transducin with Uracil Nucleotides

Biochemical and Biophysical Research Communications, 1999
Little is known about the interaction of pyrimidine nucleotides with G-proteins. Here we report that under experimental conditions that exclude transphosphorylation reactions, nucleoside 5'-triphosphates inhibited transducin-catalyzed GTP hydrolysis in the order of potency guanosine 5'-[gamma-thio]triphosphate > GTP > guanosine 5'-[beta,gamma-imido ...
J F, Klinker, R, Seifert
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Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase–uracil glycosylase inhibitor protein complex

Nature Structural & Molecular Biology, 1995
The Bacillus subtilis bacteriophages PBS-1 and PBS-2 protect their uracil-containing DNA by expressing an inhibitor protein (UGI) which inactivates the host uracil-DNA glycosylase (UDGase) base-excision repair enzyme. Also, PBS1/2 UGI efficiently inactivates UDGases from other biological sources, including the enzyme from herpes simplex virus type-1 ...
R, Savva, L H, Pearl
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Synthesis of 5-styryl derivatives of uracil nucleosides and nucleotides.

Tetrahedron Letters, 1979
Abstract Uracil nucleosides and nucleotides undergo a palladium catalyzed coupling reaction with styrenes to yield the respective 5-substituted derivatives.
Christopher F Bigge, Panos Kalaritis, Mathias P Mertes   +2 more
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Stimulation of mouse cultured sympathetic neurons by uracil but not adenine nucleotides

Neuroscience, 2001
Cultured neurons from the paravertebral sympathetic chain of rats possess excitatory P2X as well as excitatory uracil nucleotide-sensitive P2Y receptors. Preliminary observations had indicated that the analogous neurons of mice lacked P2X receptors. This difference was now investigated.
Nörenberg, Wolfgang, Göbel, Ingrid, Meyer, Angelika, Cox, Sandra Leagh, Starke, Klaus, Trendelenburg, Anne-Ulrike   +5 more
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Titania-based photocatalytic degradation of two nucleotide bases, cytosine and uracil

Applied Catalysis A: General, 2014
Abstract The photocatalytic degradation of two components of DNA and RNA, cytosine (C4H5N3O) and uracil (C4H4N2O2) differing only by the presence of an amine or a carbonyl group was investigated in the presence of UV-irradiated TiO2 aqueous suspensions.
L. Elsellami, K. Sahel, F. Dappozze, S. Horikoshi, A. Houas, C. Guillard   +5 more
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Some new derivatives of Ni(II) with uracil, uridine and nucleotides

Inorganica Chimica Acta, 1986
Abstract This paper describes the synthesis of compounds of Ni(II) with uracil, uridine and the nucleotides 5′UMP, 5′CMP, 5′GMP and 5′IMP, and their characterization, carried out by elemental analysis, by studying the infrared spectra, diffuse reflectance and conductivity measurement.
Juan J. Fiol, Angel Terron, Virtudes Moreno   +2 more
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Concentration of uracil nucleotides and UDP-glucose in mouse liver after partial hepatectomy

International Journal of Biochemistry, 1978
Abstract 1. 1. The UTP and UDP concentration of mouse liver was not significantly affected by the partial hepatectomy, whereas the size of the UMP pool increased 3- to 4-fold when compared to unoperated controls. 2. 2. In regenerating liver, the UDP-glucose concentration decreased by 20% or more when compared to unoperated controls. 3. 3.
T, Yngner, C, Engelbrecht, E, Carlberg, L, Lewan   +3 more
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Triplet state studies of the nucleoside and nucleotide derivatives of uracil and thymine

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972
Abstract Transient absorbing species due to the triplet states of uridine, 5′-uridylic acid, thymidine and 5′-thymidylic acid have been studied by flash photolysis and compared with those of the triplet states of uracil and thymine. These transients are quenched by oxygen and by their ground states with bimolecular rate constants of 6 · 10 8 , 5 · 10
D W, Whillans, H E, Johns
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