Results 131 to 140 of about 423,879 (287)

Metabolic Profiling of the EmDia Cohort by LC‐MS Reveals Empagliflozin‐Intake Associated Regulation of 1,5‐anhydroglucitol and Urate

PROTEOMICS, Volume 26, Issue 1, Page 44-56, January 2026.
ABSTRACT The EmDia trial, designed to study the effects of the sodium glucose cotransporter‐2 (SGLT2) inhibitor empagliflozin on cardiovascular comorbidities in type 2 diabetes mellitus (T2DM) patients, has been investigated for short‐term metabolic alterations by a limited set of clinical assays. To expand on this data, we report on the development of
Fabian Schmitt, Vincent ten Cate, Zlatka Fischer, Mathias Hagen, Barbara A. Steigenberger, Stefan Tenzer, Philipp S. Wild, Thierry Schmidlin   +7 more
wiley   +1 more source

Urate‐lowering therapy in patients with hyperuricemia and heart failure: A retrospective cohort study using the UK Clinical Practice Research Datalink

Clinical Cardiology
Elevated serum uric acid (sUA) is associated with heart failure (HF).
S. Kiddle, Karolina Andersson Sundell, S. Perl, Stephen Nolan, M. Bjursell   +4 more
semanticscholar   +1 more source

Uricases: reflections on recent developments in the management of challenging gout patients [PDF]

Exploration of Musculoskeletal Diseases
Oral urate-lowering therapy (ULT) is key to treating gout. However, many patients receiving oral ULT do not achieve the target serum urate (SU) levels, partly because some patients cannot tolerate or have contraindications to their use, mainly due to ...
Naomi Schlesinger, Dan Kaufmann
doaj   +1 more source

Urate-Lowering Therapy May Prevent the Development of Coronary Artery Disease in Patients With Gout [PDF]

, 2020
Fu‐Shun Yen, Chih‐Cheng Hsu, Hsin‐Lun Li, James Cheng‐Chung Wei, Chii‐Min Hwu   +4 more
openalex   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden, Jason Chai, Tafadzwa T. J. Kufazvinei, Robin P. Choudhury   +3 more
wiley   +1 more source

Kiesselbach’s area nasal septal gouty tophus with an integrated “3 + 2” diagnostic algorithm: a case report

Journal of Medical Case Reports
Background Gout, characterized by monosodium urate crystal deposition, rarely involves the nasal septum, with only a few reported cases. Such unusual presentations can mimic other conditions, necessitating prompt and accurate diagnosis.
Weikun Chen, Wanling Chen, Duanyue Guo, Ziyue Wang, Ziwen Shi, Junwei Zhong   +5 more
doaj   +1 more source

Battle of the strategies: diet versus drug therapy for gout

Современная ревматология
The best results in combating gout are achieved through a combination of diet and drug therapy. Urate-lowering therapy, which includes febuxostat, has been shown to be more effective and convenient than diet when it comes to achieving and maintaining ...
O. V. Zhelyabina, M. S. Eliseev, A. M. Lila   +2 more
doaj   +1 more source

Practical application of national clinical guidelines for the management of gout (preliminary data)

Современная ревматология, 2020
The 2018 national guidelines for the management of gout provide a consistent scheme for urate-lowering drugs; however, the possibility of achieving uric acid (UA) targets in its use has not been studied.Objective: to evaluate the effectiveness and safety
M. N. Chikina, M. S. Eliseev, O. V. Zhelyabina   +2 more
doaj   +1 more source

The independent association between parathyroid hormone levels and hyperuricemia: a national population study [PDF]

, 2012
Introduction: Increased frequencies of hyperuricemia and gout have been associated with primary hyperparathyroidism, and recent clinical trials of parathyroid hormone (PTH) have reported hyperuricemic adverse events. We evaluated the potential population
Choi, Hyon K, Choi, Jee Woong, Hui, Janet Y, Mount, David Bruce, Zhang, Yuqing, Zhu, Yanyan   +5 more
core   +1 more source

Albiflorin‐Mediated MAP2K1 Targeting and HIF‐1 Signaling Inhibition Contribute to the Therapeutic Efficacy in Hyperuricemia‐Associated Cognitive Impairment

Human Mutation, Volume 2026, Issue 1, 2026.
This study investigated the therapeutic effects and mechanisms of Paeonia suffruticosa fruit pod extract (EMP) and its main component albiflorin (AF) on hyperuricemia‐associated cognitive impairment (HUA‐CI). A HUA‐CI mouse model was established, with cognitive function evaluated via Morris water maze.
Huimin Xiao, Xinwen Huang, Rui Yao, Jincai Liu, Linrui Duan, Siwang Wang, Jinming Gao, Minghua Ren   +7 more
wiley   +1 more source