Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement and inflammation modulators. [PDF]
Sci RepUrate-lowering treatment (ULT) to target with xanthine oxidase inhibitors (XOIs) paradoxically causes early increase in gouty arthritis flares. Because delayed reduction in flare burden is mechanistically unclear, we tested for ULT inflammation ...
Sanchez C +6 more
europepmc +2 more sources
When underlying biology threatens the randomization principle - initial gout flares of urate-lowering therapy. [PDF]
Nat Rev Rheumatol, 2022 Flare is the dominant feature of gout and occurs because of inflammatory response to monosodium urate crystals; prevention of gout flares should be the major goal of gout care.
Choi HK, Zhang Y, Dalbeth N.
europepmc +2 more sources
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. [PDF]
Ann Rheum Dis, 2023 Objectives To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout.
Roddy E +8 more
europepmc +2 more sources
Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function:a randomised controlled trial [PDF]
, 2020 Background: Allopurinol has vascular antioxidant effects and participates in purinergic signalling within muscle. We tested whether allopurinol could improve skeletal muscle energetics and physical function in older people with impaired physical ...
Cavin, Ian +10 more
core +2 more sources
Controversies in Urate-Lowering Therapy for Gout: A Comprehensive Review [PDF]
Gout, Urate, and Crystal Deposition DiseaseGout is the most common inflammatory arthritis. Treatment of gout includes anti-inflammatory and urate-lowering agents. Robust guidelines by the American College of Rheumatology, the European Alliance of Associations for Rheumatology and other committees
Michael Toprover, Michael H. Pillinger
openalex +2 more sources
Effect of tart cherry juice on risk of gout attacks: protocol for a randomised controlled trial [PDF]
, 2020 Introduction: Gout is a painful form of inflammatory arthritis associated with several comorbidities, particularly cardiovascular disease. Cherries, which are rich in anti-inflammatory and antioxidative bioactive compounds, are proposed to be efficacious
Barker, Margo E +3 more
core +2 more sources
Urate-lowering therapy is associated with a reduced risk of arrhythmias: a systematic review and meta-analysis. [PDF]
J Rheum Dis, 2023 Objective While urate-lowering therapy (ULT) is linked to increased cardioprotective benefits on primary prevention of cardiovascular events such myocardial infarction or heart failure, little is known regarding their effects on arrhythmia risk.
Waitayangkoon P +8 more
europepmc +2 more sources
The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]
, 2009 Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
George, Jacob, Struthers, Allan
core +5 more sources
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]
, 2016 BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc +12 more
core +2 more sources
Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway
Nutrition & Metabolism, 2021 Objectives The study of sex differences in hyperuricemia can provide not only a theoretical basis for this clinical phenomenon but also new therapeutic targets for urate-lowering therapy.
Lei Liu +5 more
doaj +1 more source