Results 51 to 60 of about 2,566,443 (193)

Effects of Conventional Uric Acid-Lowering Therapy on Monosodium Urate Crystal Deposits. [PDF]

, 2020
Objective Few studies have systematically and quantitatively addressed the impact of urate‐lowering therapy on monosodium urate (MSU) deposits. This study was undertaken to analyze the effect of lifestyle measures and conventional urate‐lowering therapy ...
Sara Bayat, Schett, Georg, Hannah Schenker, Elizabeth Araujo, Alexander Cavallaro, Araujo, Elizabeth, David Simon, Georg Schett, Bernhard Manger, Manger, Bernhard, Ellmann, Hanna, Cavallaro, Alexander, Rech, Jürgen, Herbert S. B. Baraf, Michael Lell, Arnd Kleyer, Jürgen Rech, Hanna Ellmann, Kleyer, Arnd, Baraf, Herbert S B, Baraf, Herbert S. B., Lell, Michael, Tascilar, Koray, Bayat, Sara, Koray Tascilar, Schenker, Hannah, Simon, David   +26 more
core   +1 more source

Improved joint and patient-reported health assessments with pegloticase plus methotrexate co-therapy in patients with uncontrolled gout: 12-month exploratory outcomes of the MIRROR open-label trial

Arthritis Research & Therapy, 2022
Background Uncontrolled/refractory gout patients are recalcitrant/intolerant to oral urate-lowering therapies (ULTs), experiencing frequent gout flares, functionally limiting tophi, and low quality of life.
John K. Botson, Katie Obermeyer, Brian LaMoreaux, Lin Zhao, Michael E. Weinblatt, Jeff Peterson   +5 more
doaj   +1 more source

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

Comparison Between Early-Onset and Common Gout: A Systematic Literature Review

Rheumatology and Therapy, 2023
Introduction Gout is an inflammatory, metabolic disease associated with a high comorbidity burden including cardiovascular disease, hypertension, type 2 diabetes, hyperlipidemia, renal disease, and metabolic syndrome.
Anthony J. Amatucci, Lissa Padnick-Silver, Brian LaMoreaux, David H. Bulbin   +3 more
doaj   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

The effect of initiation of urate-lowering treatment during a gout flare on the current episode: a meta-analysis of randomized controlled trials

Advances in Rheumatology, 2022
Objective The objective was to evaluate whether initiation of urate-lowering treatment (ULT) during an acute gout flare prolonged the current episode.
Ertao Jia, Xiaoling Yao, Hongling Geng, Li Zhong, Jingjing Xie, Yuya Xiao, Yubao Jiang, Xia Qiu, Min Xiao, Yanying Zhang, Dabin Tang, Jiaxin Wei, Jianyong Zhang   +12 more
doaj   +1 more source

Effectiveness of Drug Treatments for Lowering Uric Acid on Renal Function in Patients With Chronic Kidney Disease and Hyperuricemia: A Network Meta-Analysis of Randomized Controlled Trials

Frontiers in Pharmacology, 2021
Background: Hyperuricemia is very common in patients with chronic kidney disease (CKD); the role of hyperuricemia in the occurrence and progression of kidney disease remains an interesting and unresolved issue for nephrologists, and whether urate ...
Xiang Liu, Xiang Liu, Yuxuan Qiu, Yuxuan Qiu, Duohui Li, Jiaxing Tan, Xiuping Liang, Wei Qin   +7 more
doaj   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

What is the Best Choice for Urate-lowering Therapy for Korean? [PDF]

Journal of Rheumatic Diseases, 2020
Gout is one of the most common forms of acute inflammatory arthritis caused by long-standing hyperuricemia. Various clinical and epidemiological studies have demonstrated that uric acid, which is strongly associated with the pathogenesis of gout, is closely related with increased cardiovascular (CV) risk.
Yun-Hong Cheon, Jung Soo Song
openaire   +1 more source

Evaluating Serum Urate Monitoring amongst Older Adults with Gout Initiating Urate Lowering Therapy in Ontario, Canada [PDF]

, 2023
Serum urate (SUA) monitoring plays an important role in gout management. This thesis examined whether older adults with gout received SUA monitoring after initiating urate lowering therapy (ULT).
Kwok, Timothy Shun Him
core   +1 more source