Results 61 to 70 of about 5,544 (172)

Current issues in the practical use of allopurinol in patients with gout and hyperuricemia

Современная ревматология
The cornerstone of the treatment of gout and hyperuricemia (HU) is the use of urate-lowering drugs, primarily xanthine oxidase inhibitors. Allopurinol, which has been used to treat gout for six decades, is the first line urate-lowering therapy (ULT ...
M. S. Eliseev
doaj   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, Volume 78, Issue 6, Page 781-787, June 2026.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

The genetics of gout: towards personalised medicine?

BMC Medicine, 2017
Over the last decade, there have been major advances in the understanding of the genetic basis of hyperuricaemia and gout as well as of the pharmacogenetics of urate-lowering therapy.
Nicola Dalbeth, Lisa K. Stamp, Tony R. Merriman   +2 more
doaj   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, Volume 36, Issue 51, 25 June 2026.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Kiesselbach’s area nasal septal gouty tophus with an integrated “3 + 2” diagnostic algorithm: a case report

Journal of Medical Case Reports
Background Gout, characterized by monosodium urate crystal deposition, rarely involves the nasal septum, with only a few reported cases. Such unusual presentations can mimic other conditions, necessitating prompt and accurate diagnosis.
Weikun Chen, Wanling Chen, Duanyue Guo, Ziyue Wang, Ziwen Shi, Junwei Zhong   +5 more
doaj   +1 more source

Battle of the strategies: diet versus drug therapy for gout

Современная ревматология
The best results in combating gout are achieved through a combination of diet and drug therapy. Urate-lowering therapy, which includes febuxostat, has been shown to be more effective and convenient than diet when it comes to achieving and maintaining ...
O. V. Zhelyabina, M. S. Eliseev, A. M. Lila   +2 more
doaj   +1 more source

Uricases: reflections on recent developments in the management of challenging gout patients [PDF]

Exploration of Musculoskeletal Diseases
Oral urate-lowering therapy (ULT) is key to treating gout. However, many patients receiving oral ULT do not achieve the target serum urate (SU) levels, partly because some patients cannot tolerate or have contraindications to their use, mainly due to ...
Naomi Schlesinger, Dan Kaufmann
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

A prospective clinical study on the efficacy and safety of specific uric acid adsorption hemoperfusion in removing serum uric acid from patients with refractory gout

Zhongguo shuxue zazhi
[Objective] To evaluate the efficacy and safety of the single-use hemoperfusion device (UA230) in treating refractory gout (RG) via plasma perfusion. [Methods] Thirty-four RG patients aged 18-65 years were recruited and randomly divided into a control ...
LI Ying, YANG Yuanming, JING Zhongcui, LIU Jiao, JIANG Dandan, YU Shanshan, WANG Haiyan   +6 more
doaj   +1 more source

Development of a multivariable improvement measure for gout

Arthritis Research & Therapy, 2020
Background Gout is a heterogeneous inflammatory disease with numerous clinical manifestations. A composite means to assess the impact of therapy on numerous aspects of gout could be useful.
Naomi Schlesinger, N. Lawrence Edwards, Anthony E. Yeo, Peter E. Lipsky   +3 more
doaj   +1 more source