Results 81 to 90 of about 2,566,443 (193)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, Volume 13, Issue 56, 9 October 2026.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Management of gout: Primary care approach

South African Family Practice, 2009
Great strides have been made in understanding gout as a disease over the centuries. Despite these advances, reports suggest that the management of gout is relatively sub-optimal at the primary care level.
Olufemi Omole, Gboyega A. Ogunbanjo
doaj   +1 more source

Multisystem Complications in Non‐Transfusion‐Dependent β‐Thalassemia Intermedia: A Case Highlighting the Need for Early Intervention

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This case highlights that severe complications of non‐transfusion‐dependent β‐thalassemia may be preventable with appropriate monitoring and timely intervention; however, once established, multisystem complications can be challenging to treat.
Oldooz Aloosh, Seyedeh Esmat Hosseini, Mohammad Karimi   +2 more
wiley   +1 more source

Cardiovascular events in patients with gout initiating urate-lowering therapy with or without colchicine for flare prophylaxis: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data [PDF]

BackgroundInitiating urate-lowering therapy can trigger gout flares. Gout flares have been associated with a temporally increased risk of cardiovascular events.
Avery, Anthony, Choi, Hyon, Abhishek, Abhishek, McCormick, Natalie, Yokose, Chio, Mamas, Mamas, Tata, Laila, Nakafero, Georgina, Cipolletta, Edoardo   +8 more
core   +1 more source

Urate-lowering therapy in maintenance hemodialysis: focusing on gout burden rather than serum urate alone

Renal Replacement Therapy
Background Whether asymptomatic hyperuricemia should trigger pharmacologic intervention in maintenance hemodialysis remains unresolved. This question differs fundamentally from hyperuricemia management in the general population or in nondialysis chronic ...
Yoshitaka Furuto, Daiki Yoshino, Akio Namikawa, Dai Sato, Yuko Shibuya   +4 more
doaj   +1 more source

Titanium Dioxide Exacerbates Calcium Phosphate and Urate‐Induced Oxidative Stress, Injury and Inflammatory Response in Human Kidney‐2 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Graphical summary of the proposed mechanism displaying the synergistic effects of titanium dioxide nanoparticles (TNPs) exacerbating renal injury induced by CaP and UA crystals in HK2 cells. Store operated Ca2+ entry (SOCE) mediated Ca2+ influx promotes enhanced oxidative stress, activating inflammatory, fibrotic, and apoptotic pathways.
Samshritha R. Bikki, Aditi Mohapatra, Samuel Shin, Bidhan C. Bandyopadhyay   +3 more
wiley   +1 more source

A Post–NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Mohammed Solayman Hossain, Sukyung Kim, Md Tareque Aziz, Izaz Ahmed, Md Sarower Hossen Shuvo, Hyewon Yang, Yunjeong Jang, Minseo Kim, Seohyeon Jang, Yusol Kim, Soeun Oh, Yunseo Nam, Hoonhee Seo, Ho‐Yeon Song   +13 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Inflammatory Bowel Disease Is Associated With an Increased Risk of End‐Stage Renal Disease: A Population‐Based Cohort Study

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1110-1122, October 2026.
In a retrospective population‐based cohort study using the University of Manitoba IBD Epidemiology Database, persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD ...
Onuma Sattayalertyanyong, Zoann Nugent, Bryce Barr, Keevin N. Bernstein, Charles N. Bernstein   +4 more
wiley   +1 more source

Current issues in the practical use of allopurinol in patients with gout and hyperuricemia

Современная ревматология
The cornerstone of the treatment of gout and hyperuricemia (HU) is the use of urate-lowering drugs, primarily xanthine oxidase inhibitors. Allopurinol, which has been used to treat gout for six decades, is the first line urate-lowering therapy (ULT ...
M. S. Eliseev
doaj   +1 more source