Results 161 to 170 of about 2,310,068 (246)

Genotypic and clinical characteristics of long-term surviving adult patients with urea cycle disorders in Japan. [PDF]

Orphanet J Rare Dis
Kido J, Sugawara K, Yano N, Nakamura K.
europepmc   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Genipin induces liver injury by disrupting the CPS1-regulated urea cycle and redox homeostasis. [PDF]

J Pharm Anal
Xu H, Huang X, Zhang Y, Gong S, Luo Y, Fang Y, Hu X, Luo M, Zhai Y, Gao F, Chen X, Zhang R, Zhao L, Wang Y, Wu JL, Zhang X, Liang H, Wen J, Zhou T.   +18 more
europepmc   +1 more source

Nickelferrite on Pnictogen Functionalized Carbon Nanohorns. Bifunctional ORR and OER Catalysts in Rechargeable Zinc‐Air Batteries

Advanced Science, EarlyView.
A systematic study on the performance of N,P‐doped NiFe2O4@CNH bi‐functional hybrid electrocatalysts for rechargeable zinc‐air batteries is presented. The importance of P, N‐doping and the intimate tethering of nickel‐ferrite nanocubes on the carbon nano‐horn (CNH) surface which are well dispersed on the surface of N,P doped CNHs.
Sudheer Kumar Yadav, Vanessa Trouillet, Jonas Lins, Torsten Gutmann, Jörg J. Schneider   +4 more
wiley   +1 more source

Urea cycle modulation by combined SGLT2 inhibitors and metformin. [PDF]

BMC Med
Harada M, Adam J, Han S, Shi M, Ge J, Lintelmann J, Cecil A, Zukunft S, Prehn C, Witting M, Scheerer MF, Neschen S, Irmler M, Beckers J, Adamski J, Teupser D, Linkohr B, Gieger C, de Angelis MH, Peters A, Wang-Sattler R.   +20 more
europepmc   +1 more source

Bioinspired Metastable Transient Peeling for Repeatable Rapid Release

Advanced Science, EarlyView.
Inspired by the explosive seed ejection of the squirting cucumber, this work introduces metastable transient peeling that temporally regulates stored interfacial energy release via a tunable energy barrier. A viscoelastic hemispherical gripper achieves 52 ms ultrafast, residue‐free release with 300 000‐cycle durability, enabling damage‐free handling of
Lvzhou Li, Qingyue Li, Yao Hu, Xu Dong, Xiangli Wen, Kai Zhu, Yaoyao Jiang, Yu Tian, Jianning Ding   +8 more
wiley   +1 more source

Urea cycle fumarate limits fibrosis post-myocardial infarction by reducing fibroblast mitochondrial adenosine triphosphate production. [PDF]

Cardiovasc Res
Zhao J, Ruan Y, Chen Y, Chen Q, Hong T, Wang L, Xu Y, Hou L, Liao F, Yin D, Ni C.   +10 more
europepmc   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Ammonification Process Is Limited by Transformation of Medium Molecular Weight Nitrogenous Organics but Not Hydrolysis of Proteins

Advanced Science, EarlyView.
A multi‐level analytical framework, integrating protein‐level persistence analysis, nontargeted HRMS formula tracking, peptide‐level proteomics, and targeted monomer quantification under varying redox conditions, together with FMO calculations reveal that ammonification is limited by medium molecular weight nitrogenous multimers.
Jing Li, Junjie Qiu, Fan Lü, Hua Zhang, Pinjing He   +4 more
wiley   +1 more source

High salt supplementation of a MASH-inducing diet causes lean MASH phenotype with increased hepatic urea cycle activity and EIF5A hypusination. [PDF]

Mol Metab
Luo S, Morisawa N, Widjaja AA, Singh BK, Hausenloy DJ, Yen PM, Zhou J.   +6 more
europepmc   +1 more source