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Modeling of flux, binding and substitution of urea molecules in the urea transporter dvUT [PDF]
Journal of Molecular Graphics and Modelling, 2017 Xian-Wu Zou, Xiaoqin Zou
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Comprehensive Physiology, 2011
Abstract Urea transport proteins were initially proposed to exist in the kidney in the late 1980s when studies of urea permeability revealed values in excess of those predicted by simple lipid‐phase diffusion and paracellular transport. Less than a decade later, the first urea transporter was cloned.
Janet D, Klein +2 more
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Abstract Urea transport proteins were initially proposed to exist in the kidney in the late 1980s when studies of urea permeability revealed values in excess of those predicted by simple lipid‐phase diffusion and paracellular transport. Less than a decade later, the first urea transporter was cloned.
Janet D, Klein +2 more
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Current Opinion in Nephrology and Hypertension, 1996
Urea transporters are membrane proteins that mediate rapid, passive movement of urea across cell membranes. Physiological studies have revealed their significant roles in urea accumulation in the kidney inner medulla, and consequently in the urinary concentrating mechanism.
C, Shayakul, M A, Hediger
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Urea transporters are membrane proteins that mediate rapid, passive movement of urea across cell membranes. Physiological studies have revealed their significant roles in urea accumulation in the kidney inner medulla, and consequently in the urinary concentrating mechanism.
C, Shayakul, M A, Hediger
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Current Opinion in Nephrology and Hypertension, 2004
Urea is transported across the kidney inner medullary collecting duct by urea-transporter proteins. Two urea-transporter genes have been cloned from humans and rodents: the UT-A (Slc14A2) gene encodes five protein and eight cDNA isoforms; the UT-B (Slc14A1) gene encodes a single isoform.
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Urea is transported across the kidney inner medullary collecting duct by urea-transporter proteins. Two urea-transporter genes have been cloned from humans and rodents: the UT-A (Slc14A2) gene encodes five protein and eight cDNA isoforms; the UT-B (Slc14A1) gene encodes a single isoform.
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Annual Review of Physiology, 2003
▪ Abstract Urea plays a key role in the urine-concentrating mechanism. Physiologic and molecular data demonstrate that urea transport in kidney and red blood cells occurs by specific urea transporter proteins. Two gene families for facilitated urea transporters, UT-A and UT-B, and several urea transporter cDNA isoforms have been cloned from human ...
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▪ Abstract Urea plays a key role in the urine-concentrating mechanism. Physiologic and molecular data demonstrate that urea transport in kidney and red blood cells occurs by specific urea transporter proteins. Two gene families for facilitated urea transporters, UT-A and UT-B, and several urea transporter cDNA isoforms have been cloned from human ...
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Urea transporters in kidney and erythrocytes
American Journal of Physiology-Renal Physiology, 1997Physiological and molecular data demonstrate that urea transport in kidney and erythrocytes is regulated by specific urea transporter proteins. The urea transporter in the terminal inner medullary collecting duct permits very high rates of regulated transepithelial urea transport and results in the delivery of large amounts of urea into the deepest ...
J M, Sands, R T, Timmer, R B, Gunn
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Transport Characteristics of Urea Transporters
Rapid urea permeation mediated by urea transporters (UTs) is crucial for maintaining normal physiological processes in organisms. UTs not only facilitate urea transport but also water transport, further underscoring their role in maintaining fluid balance.Zhizhen, Huang, Baoxue, Yang
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Urea transport in the dogfish kidney
Journal of Experimental Zoology, 1977AbstractThere is increasing evidence that urea movement across many epithelia involves more than passive diffusion. Of particular interest is the observation that urea transport across the erythrocyte membrane and across the vasopressin‐stimulated urinary bladder of the toad occurs by facilitated diffusion, and can be selectively inhibited by phloretin
R M, Hays +6 more
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Urea Transport Mediated by Membrane Proteins of Non-urea-Transporters
Urea is generated by the urea cycle enzymes, which are mainly in the liver but are also ubiquitously expressed at low levels in other tissues of mammals. Urea is then eliminated through fluids, especially urine. Urea also serves as a readily available nitrogen source for the growth of many organisms, including plants and bacteria. Urea transporters areMinghui, Wang +2 more
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Genes and Proteins of Urea Transporters
2014A urea transporter protein in the kidney was first proposed in 1987. The first urea transporter cDNA was cloned in 1993. The SLC14a urea transporter family contains two major subgroups: SLC14a1, the UT-B urea transporter originally isolated from erythrocytes; and SLC14a2, the UT-A group originally isolated from kidney inner medulla.
Jeff M, Sands, Mitsi A, Blount
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