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Gene structure of urea transporters
American Journal of Physiology-Renal Physiology, 2003Urea plays various roles in the biology of diverse organisms. The past decade has produced new information on the molecular structure of several urea transporters in various species. Availability of DNA probes has revealed that the presence of urea transporters is not confined to the mammalian kidney but is also evident in testis and brain, raising new
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Role and regulation of urea transporters
Pflügers Archiv - European Journal of Physiology, 2005In the past few years, significant knowledge has been gained about the physiological role and regulation of urea transporters, which have been now cloned in many species. The two major mammalian urea transporters, UT-A and UT-B, have been best studied in the kidney, where they mediate the facilitated diffusion of urea across tubular, interstitial, and ...
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Clinical Aspects of Urea Transporters
2014Jk antigens, which were identified as urea transporter B (UT-B) in the plasma membrane of erythrocytes, and which determine the Kidd blood type in humans, are involved in transfusion medicine, and even in organ transplantation. The Jk(a-b-) blood type is a consequence of a silent Slc14A1 gene caused by various mutations related to lineage. In addition,
Jianhua, Ran, Hongkai, Wang, Tinghai, Hu
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Protein Structures of Urea Transporters
Urea transporters (UTs) facilitate the rapid transport of urea from the extracellular space to the intracellular space through a selective transport mechanism driven by urea concentration gradients. Advances in Cryo-electron microscopy and X-ray crystallography have enabled us to solve the homotrimer structures of UT-A and UT-B, which share a common ...Mengyao, Xiong +3 more
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Facilitative Urea Transporters
Journal of Membrane Biology, 2001Smith, C. P., Rousselet, G.
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Genes and Evolution of Urea Transporters
Urea transporters (UTs) are a group of membrane channel proteins that specifically facilitate the permeation of urea, from bacteria to mammals, playing an essential role in urea reabsorption and water conservation. In mammals, there are two subfamilies of UT: the UT-A group originally isolated from the kidney inner medulla, and UT-B originally isolatedYi, Ying +3 more
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Physiological Functions of Urea Transporters
Urea transporters (UTs) are a group of membrane channel proteins that specifically facilitate the permeation of urea, which play an essential role in urea reabsorption and water conservation. There are 4 isoforms, UT-A1, UT-A2, UT-A3, UT-B, that are expressed in the kidney to maintain the urea recycle and establish the urea concentration gradient in ...Zhiwei, Qiu +3 more
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Expression of Urea Transporters and Their Regulation
2014UT-A and UT-B families of urea transporters consist of multiple isoforms that are subject to regulation of both acutely and by long-term measures. This chapter provides a brief overview of the expression of the urea transporter forms and their locations in the kidney.
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Seminars in nephrology, 1993
Urea transport within the kidney is regulated and varies dramatically between different nephron segments. The terminal IMCD displays very high rates of transepithelial urea transport enabling delivery of large amounts of urea into the deepest portions of the inner medulla to maintain a high interstitial osmolality for concentrating the urine maximally.
A G, Gillin, J M, Sands
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Urea transport within the kidney is regulated and varies dramatically between different nephron segments. The terminal IMCD displays very high rates of transepithelial urea transport enabling delivery of large amounts of urea into the deepest portions of the inner medulla to maintain a high interstitial osmolality for concentrating the urine maximally.
A G, Gillin, J M, Sands
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