Discovery of novel diarylamides as orally active diuretics targeting urea transporters [PDF]
Acta Pharmaceutica Sinica B, 2021 Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics. In the present study,
Shuyuan Wang, Yue Xu, Xiaoqiang Geng
exaly +4 more sources
Investigation of facilitative urea transporters in the human gastrointestinal tract [PDF]
Physiological Reports, 2018 The symbiotic relationship between humans and their intestinal microbiome is supported by urea nitrogen salvaging. Previous studies have shown that colonic UT‐B urea transporters play a significant role in this important physiological process.
Caragh Walpole +5 more
doaj +3 more sources
Regional investigation of UT-B urea transporters in the rat brain [PDF]
Biochemistry and Biophysics Reports, 2023 Recent studies have reported increased levels of urea in the aging brain and various neurological disorders. Additionally, these diseased tissues also have increased expression of the UT-B transporter that regulates urea transport in the brain.
Farhana Pinki +2 more
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Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters [PDF]
Molecules, 2022 Urea transporter (UT) inhibitors are a class of promising novel diuretics that do not cause the imbalance of Na+, K+, Cl−, and other electrolytes. In our previous studies, 25a, a promising diuretic candidate inhibiting UT, was discovered and showed ...
Yue Xu +6 more
doaj +2 more sources
Urea Transporters in Cancer: Emerging Roles and Their Clinical Implications [PDF]
BiomedicinesBackground/Objective: The SLC14A gene family in mammals encodes the urea transporters UT-A and UT-B (UTs), whose primary function is urea transport. In recent years, increasing research has shown that UTs are involved in tumor formation and progression ...
Huimin Sun +4 more
doaj +2 more sources
Osmotic regulation of UT‐B urea transporters in the RT4 human urothelial cell line [PDF]
Physiological Reports, 2019 Facilitative UT‐B urea transporters play important physiological roles in numerous tissues, including the urino‐genital tract. Previous studies have shown that urothelial UT‐B transporters are crucial to bladder function in a variety of mammalian species.
Alan Farrell, Gavin Stewart
doaj +2 more sources
Structure of urea transporters. [PDF]
Subcell Biochem, 2014 Members of the urea transporter (UT) family mediate rapid, selective transport of urea down its concentration gradient. To date, crystal structures of two evolutionarily distant UTs have been solved. These structures reveal a common UT fold involving two structurally homologous domains that encircle a continuous membrane-spanning pore and indicate that
Levin EJ, Zhou M.
europepmc +4 more sources
Water transport mediated by murine urea transporters: implications for urine concentration mechanisms [PDF]
Biology Open, 2020 Urea transporters (UTs) facilitate urea diffusion across cell membranes and play an important role in the urinary concentration mechanisms in the kidney.
J. Kabutomori +2 more
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The Physiological Roles and Pathological Implications of Urea Transporters in the Cardiovascular System [PDF]
BiomedicinesUrea transporter (UT) proteins are a group of membrane proteins specifically facilitating the transmembrane transport of urea, primarily divided into the UT-A and UT-B subfamilies.
Guangying Shao +5 more
doaj +2 more sources
Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters [PDF]
Nature CommunicationsUrea’s transmembrane transport through urea transporters (UT) is a fundamental physiological behavior for life activities. Here, we present 11 cryo-EM structures of four UT members in resting states, urea transport states, or inactive states bound with ...
Shen-Ming Huang +25 more
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