Results 31 to 40 of about 25,978 (275)

Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase. [PDF]

PLoS ONE, 2014
The urea cycle converts ammonia, a waste product of protein catabolism, into urea. Because fish dispose ammonia directly into water, the role of the urea cycle in fish remains unknown.
Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka   +6 more
doaj   +1 more source

A deep intronic variant is a common cause of OTC deficiency in individuals with previously negative genetic testing

Molecular Genetics and Metabolism Reports, 2021
Pathogenic variants in non-coding regions of genes encoding enzymes or transporters of the urea cycle can lead to urea cycle disorders (UCDs). However, not all commercially available testing platforms interrogate these regions. Here, we used a gene panel
Runjun D. Kumar, Lindsay C. Burrage, Jan Bartos, Saima Ali, Eric Schmitt, Sandesh C.S. Nagamani, Cynthia LeMons   +6 more
doaj   +1 more source

Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters.

Am J Physiol Renal Physiol, 2014
Urea transporters (UT) play an important role in the urine concentration mechanism by mediating intrarenal urea recycling, suggesting that UT inhibitors could have therapeutic use as a novel class of diuretic.
Ren H, Wang Y, Xing Y, Ran J, Liu M, Lei T, Zhou H, Li R, Sands JM, Yang B.   +9 more
europepmc   +2 more sources

Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells

Biomolecules, 2023
In respiring mitochondria, the proton gradient across the inner mitochondrial membrane is used to drive ATP production. Mitochondrial uncouplers, which are typically weak acid protonophores, can disrupt this process to induce mitochondrial dysfunction ...
Edward York, Daniel A. McNaughton, Meryem-Nur Duman, Philip A. Gale, Tristan Rawling   +4 more
doaj   +1 more source

First person – Jessica Kabutomori

Biology Open, 2020
First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers.
doaj   +1 more source

Cytokine-mediated regulation of urea transporters during experimental endotoxemia

, 2007
Acute renal failure (ARF) is a frequent complication of sepsis and has a high mortality. Sepsis-induced ARF is known to be associated with significant impairment of tubular capacity.
Bucher, Michael, Höcherl, Klaus, Schmidt, Christoph   +2 more
core   +1 more source

Amino acid transporter inventory of the Selaginella genome

Frontiers in Plant Science, 2012
Amino acids play fundamental roles in a multitude of functions including protein synthesis, hormone metabolism, nerve transmission, cell growth, production of metabolic energy, nucleobase synthesis, nitrogen metabolism and urea biosynthesis.
Daniel eWipf, Dominique eLoqué, Sylvie eLalonde, Wolf B Frommer   +3 more
doaj   +1 more source

The Ins and Outs of Urea: Identification of Putative DUR3-like Urea Transporters in the Oligohaline Nerite Snail Theodoxus fluviatilis and Their Expression under Changing Salinities

Physiologia, 2023
Theodoxus fluviatilis (Linnaeus, 1758) (Gastropoda: Neritidae) is an oligohaline aquatic gastropod that inhabits most of Europe and adjacent areas of Asia.
Jan Knobloch, Sarah Gößeler, Laura I. R. Fuchs, Janina Fuß, Montserrat Torres-Oliva, Christian Müller, Jan-Peter Hildebrandt   +6 more
doaj   +1 more source

Urea transport in Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1975
Urea transport in Saccharomyces cerevisiae occurs by two pathways. The first mode of uptake is via an active transport system which: (i) has an apparent Km value of 14 muM, (ii) is absolutely dependent upon energy metabolism, (iii) requires pre-growth of the cultures in the presence of oxaluric acid, gratuitous inducer of the allantoin degradative ...
T G, Cooper, R, Sumrada
openaire   +2 more sources

Structural Studies of a Urea Channel with Electron Microscopy [PDF]

, 2013
The Urea/Amide channel from Bacillus cereus (UACBc) was expressed in Escherichia coli with a C-terminal hexa-histidine tag. The protein was purified in detergent as confirmed by N-terminal sequencing.
Chan, Nathan
core