Fluorinated tetrapodal anion transporters [PDF]
iScience, 2023 Summary: Synthetic anion transporters show potential in treating life-threatening diseases like cystic fibrosis and cancer. However, with increasingly complex transporter architectures designed to control anion binding and transport, it is important to ...
Alexander M. Gilchrist +4 more
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Mammalian urea transporters [PDF]
Experimental Physiology, 2009 Urea transporters (UTs) encoded by the Slc14a1 (UT‐B) and Slc14a2 (UT‐A) genes mediate urea flux across cellular membranes. Considerable research has accrued detailing the function and distribution of members of both subfamilies. Much research effort has focused on the kidney, where UTs are highly expressed and function to promote urine concentration ...
Smith, Craig P., Craig P. Smith
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Modelling and mutational analysis of Aspergillus nidulans UreA, a member of the subfamily of urea/H+ transporters in fungi and plants [PDF]
Open Biology, 2014 We present the first account of the structure–function relationships of a protein of the subfamily of urea/H+ membrane transporters of fungi and plants, using Aspergillus nidulans UreA as a study model.
Manuel Sanguinetti +4 more
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Scientific Reports, 2023 The milk urea concentration (MUC) serves as indicator of urinary nitrogen emissions, but at comparable crude protein (CP) intake, cows with high (HMU) and low (LMU) MUC excrete equal urea amounts.
Marie C. Prahl +3 more
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Altered Renal Expression of Relevant Clinical Drug Transporters in Different Models of Acute Uremia in Rats. Role of Urea Levels [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Organic anion transporter 1 (Oat1) and 3 (Oat3) are organic anion transporters that play critical roles in the body disposition of numerous clinically important drugs.
Anabel Brandoni, Adriana M. Torres
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Structural characterization of human urea transporters UT-A and UT-B and their inhibition. [PDF]
Sci Adv, 2023 In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B inhibition by its selective inhibitor, UTBinh-14.
Chi G +14 more
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Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats [PDF]
Kidney International, 2015 © 2015 International Society of Nephrology Inhibitors of kidney urea transporter (UT) proteins have potential use as salt-sparing diuretics (‘urearetics’) with a different mechanism of action than diuretics that target salt transporters.
Onur Cil +2 more
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DUR3 as a Molecular Lever for Coordinated Nitrogen and Phosphorus Uptake in Microalgae [PDF]
BiologyNitrogen (N) and phosphorus (P) are essential macronutrients for plant growth and major pollutants driving aquatic eutrophication. Microalgae represent a sustainable biological platform for nutrient recovery and circular utilization from wastewater ...
Geliang Ji +8 more
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Solute carrier transporters: potential targets for digestive system neoplasms
Cancer Management and Research, 2018 Jing Xie,1,2 Xiao Yan Zhu,1,2 Lu Ming Liu,1,2 Zhi Qiang Meng1,2 1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of
Xie J, Zhu XY, Liu LM, Meng ZQ
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Predicting the functionality of major intrinsic proteins: An in silico analysis in Musa [PDF]
Trends in Pharmaceutical Sciences, 2016 Major intrinsic proteins (MIPs) are tetrameric complexs with six transmembrane domains. MIPs which are involved in water and nutrient permeability have been called aquaporins and aquaglyceroporins respectivly.
Shiva Hemmati
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