Results 111 to 120 of about 25,978 (275)

Increased urea nitrogen salvaging by a remodeled gut microbiota helps nonhibernating pikas maintain protein homeostasis during winter.

PLoS Biology
Nitrogen balance is a major challenge for herbivores when consuming a low-nitrogen diet. Gut microbiota-mediated urea nitrogen recycling facilitates protein homeostasis during times of nitrogen deficiency, yet its relevance to wild nonhibernating small ...
Fuyu Shi, Desheng Zou, Liangzhi Zhang, Na Guo, Jiangkun Yu, Abraham Allan Degen, Xianjiang Tang, Shien Ren, Yuning Ru, Shuai Zheng, Yanming Zhang, Dehua Wang   +11 more
doaj   +1 more source

Vasopressin activates collecting duct urea transporters and water channels by distinct physical processes

, 1993
The present studies were performed to investigate the kinetics of regulation of water channels and urea carriers in the rat terminal (IMCD) in response to vasopressin (AVP).
S. Nielsen, M. A. Knepper
core   +1 more source

Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices

Advanced Science, EarlyView.
Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen, Wei Zeng, Zherui Zhao, JiYu Zhao, Ziyan Huang, Zhuo Chen, Kui Zhou, Guanglong Ding, Su‐Ting Han, Ye Zhou   +9 more
wiley   +1 more source

Control of H(+)-HCO3- plasma membrane transporters by urea hyperosmolality in rat medullary thick ascending limb

, 1994
Hyperosmolality inhibits bicarbonate absorption by the rat medullary thick ascending limb (MTAL) by unknown mechanisms. Intracellular pH (pHi) was monitored with use of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein in rat MTAL tubule suspensions to ...
F. Leviel, M. Bichara, M. Froissart, H. Soualmia, J. Poggioli, M. Paillard   +5 more
core   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Highly Efficient and Environmentally Stable Radiative Cooling Fabric: Integrating Photoluminescence and Hierarchical Core–Shell Fibers

Advanced Science, EarlyView.
A scalable radiative cooling fabric engineered with a multi‐layer assembly core–shell structure and integrated photoluminescent materials is reported. The fabric exhibits remarkable environmental stability, including UV resistance, mechanical durability, hydrophobicity, stain resistance, thermal stability, and flame retardancy, demonstrating its ...
Hongtao Liu, Hui Li, Yining Wang, Wei Sun, Zhuan Chen, Yongping Hou, Yongmei Zheng, Xuejian Chen, Bin Yu   +8 more
wiley   +1 more source

Vasopressin regulation of the renal UT-A3 urea transporter

, 2009
Facilitative urea transporters in the mammalian kidney play a vital role in the urinary concentrating mechanism. The urea transporters located in the renal inner medullary collecting duct, namely UT-A1 and UT-A3, are acutely regulated by the antidiuretic
Thistlethwaite, A., Lees, H., G. S. Stewart, A. Thistlethwaite, Cooper, G. J., H. Lees, G. J. Cooper, Craig Smith, Stewart, G. S., Smith, Craig   +9 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Urea cycle.

, 2016
In the urea cycle the “toxin” ammonium (NH4+) is converted to non-toxic urea by five consecutive enzymatic reactions in the liver. In hepatocytes, the rate-limiting, ATP-dependent enzyme carbamoyl phosphate synthetase 1 (CPS1), which is allosterically ...
Matthias Gautschi (2608306), Tamar Stricker (2608312), Adrian Keogh (174242), Johannes Häberle (719209), Renata C. Gallagher (2608315), Alexander Laemmle (174189), Jean-Marc Nuoffer (334268), Matthias R. Baumgartner (2608309)   +7 more
core   +1 more source

Optimization of SWCNT‐FET Biosensors by Aptamer Engineering and Toehold‐Mediated Strand Displacement

Advanced Science, EarlyView.
Aptamer‐based single‐walled carbon nanotube (SWCNT) field‐effect transistor (FET) biosensors are developed for label‐free, real‐time biomarker detection. Truncated DNA aptamers enhance sensitivity through improved conformational switching. A toehold‐mediated strand displacement (TMSD) strategy optimizes functionalization and simplifies fabrication. The
Haosen Miao, Tingting Zheng, Houlin Yu, Gririraj Manoharan, Gustavo Sant'Anna, Nicholas Bedfrod, Jorge L. Chávez, Chang‐Seuk Lee, Matteo Palma   +8 more
wiley   +1 more source