Results 121 to 130 of about 25,978 (275)

Characterization of mouse urea transporters UT-A1 and UT-A2

, 2002
Specialized transporter proteins that are the products of two closely related genes, UT-A (Slc14a2) and UT-B (Slc14a1), modulate the movement of urea across cell membranes.
Fenton, R. A., Potter, E. A., Cooper, G. J., Carpenter, B., Howorth, A., Smith, C. P., Stewart, G. S.   +6 more
core   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

N-acetylglutamate synthase deficiency: an insight into the genetics, epidemiology, pathophysiology, and treatment

The Application of Clinical Genetics, 2011
Nicholas Ah Mew, Ljubica CaldovicCenter for Genetic Medicine Research, Children’s Research Institute, Children’s National Medical Center, Washington DC, USAAbstract: The conversion of ammonia into urea by the human liver requires the ...
Caldovic L, Ah Mew N
doaj  

Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney. [PDF]

J Am Soc Nephrol, 2020
Laszczyk AM, Higashi AY, Patel SR, Johnson CN, Soofi A, Abraham S, Dressler GR.   +6 more
europepmc   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters. [PDF]

Acta Pharmacol Sin, 2020
Li M, Zhao Y, Zhang S, Xu Y, Wang SY, Li BW, Ran JH, Li RT, Yang BX.   +8 more
europepmc   +1 more source

Ammonia transport mediated by urea transporter A isoforms

Biology Open
ABSTRACT Urea transporters (UTs) are a family of urea-selective channel proteins that play an essential role in the urine-concentrating mechanism of the mammalian kidney. In addition to urea, UT-A2 and UT-A3 – the N- and C-terminal regions of full-length UT-A1, respectively – and UT-B transport water, and human UT-B transports water and ...
N. Pina-Lopes, J. Kabutomori, R. Campos, R. Musa-Aziz   +3 more
openaire   +3 more sources

Current role of enzyme analysis for urea cycle disorders

, 2014
Urea cycle disorders (UCD) are due to defects of any of its six enzymes or two transporters. The definitive diagnosis of defects of the three mitochondrial enzymes, N-acetylglutamate synthase (NAGS), carbamylphosphate synthetase I (CPS1) and ornithine ...
Eggimann, Sandra, Nuoffer, Jean-Marc, Gautschi, Matthias   +2 more
core   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats

, 2002
Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats.BackgroundLithium is commonly used to treat bipolar psychiatric disorders but can cause reduced urine concentrating ability.MethodsTo test whether lithium alters UT-A1 or
Sands, Jeff M., Gunn, Robert B., Robert B. Gunn, Klein, Janet D., Roberts, Brian R., Brian R. Roberts, Jeff M. Sands, Janet D. Klein   +7 more
core   +1 more source