Results 51 to 60 of about 1,080,434 (247)

Sistema de microencapsulação de urease com quitosana - PVA : reatividade e aplicações [PDF]

, 1997
Tese (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas.Neste trabalho foi investigada a microencapsulação da urease na forma de extrato bruto (EE), através do método de coacervação salina, utilizando-se o ...
Miguez, Maria Jose Brandão
core  

Gossypol from Gossypium spp. Inhibits Helicobacter pylori Clinical Strains and Urease Enzyme Activity: Bioactivity and Safety Assessments

Scientia Pharmaceutica, 2022
This study investigates the inhibitory activities of gossypol, a natural polyphenolic compound from Gossypium spp., against Helicobacter pylori (HP) clinical strains and a urease enzyme that plays a key role in the pathogenesis of HP.
Miroslava Šudomová, Sherif T. S. Hassan   +1 more
doaj   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

with antioxidant and urease inhibitory activity [PDF]

, 2021
Urease plays a significant role in the pathogenesis of urolithiasis pyelonephritis, urinary catheter encrustation, hepatic coma, hepatic encephalopathy, and peptic acid duodenal ulcers.
Abdullah, Iskandar, Farooq Saleem, Choudhary, M. Iqbal, Nadra Naheed, Naheed, Nadra, Maher, Saima, Mirza, Muhammad Usman, Trant, John F., Muhammad Usman Mirza, Khan, Ajmal, Wadood, Abdul, John F. Trant, Saleem, Farooq, Abdul Wadood, Ajmal Khan, Froeyen, Matheus, Matheus Froeyen, Saima Rasheed, M. Iqbal Choudhary, Iskandar Abdullah, Rasheed, Saima, Sarfraz Ahmad, Ahmad, Sarfraz, Saima Maher   +23 more
core   +1 more source

Unveiling Urease Inhibitory Properties and Phytochemical Screening for the Therapeutic Potential of Extracts and Fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr

Exon
Urease is an enzyme that plays a significant role in the pathogenesis of Helicobacter pylori responsible for numerous health issues, among which chronic gastritis, peptic ulcer disease, gastric neoplasia and even stomach cancer.
Doriane Perlise Lienou, Corinne Raïssa Ngnameko, Fils Armand Ella, Marie Atsama Amougou, Arnaud Fondjo Kouam, Jacqueline Njikam Manjia, Fredy Brice Nemg Simo, Frederic Nico Njayou, Paul Fewou Moundipa   +8 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

Synthesis of New Coumarin-C3 Benzimidazole Hybrids and Their Urease Inhibition Studies

, 2023
A novel series of coumarin-benzimidazole hybrids were designed, synthesized, and extensively characterized using spectral data, including FT-IR, H-1-NMR, and C-13-NMR.
Akyüz, Gülay, Gülay Akyüz, Emre Menteşe, Menteşe, Emre   +3 more
core   +1 more source

Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation

Frontiers in Chemistry
The urease enzyme is recognized as a valuable therapeutic agent for treating the virulent Helicobacter pylori bacterium because of its pivotal role in aiding the colonization and growth of the bacterium within the gastric mucosa.
Muhammad Akash, Nehal Rana, Sana Aslam, Matloob Ahmad, Muhammad Jawwad Saif, Aneeza Asghar, Sadia Sultan, Sadia Sultan, Sami A. Al-Hussain, Afifa Liaqat, Sumera Zaib, Magdi E. A. Zaki   +11 more
doaj   +1 more source