The effect of three urease inhibitors on H. pylori viability, urease activity and urease gene expression [PDF]
Frontiers in MicrobiologyBackgroundTreatment of Helicobacter pylori (H. pylori) infections is challenged by antibiotic resistance. The urease enzyme contributes to H. pylori colonization in the gastric acidic environment by producing a neutral microenvironment.
Hanaa Shaalan +3 more
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Unraveling Binding Mechanism and Stability of Urease Inhibitors: A QM/MM MD Study [PDF]
Molecules, 2023 Soil bacteria can produce urease, which catalyzes the hydrolysis of urea to ammonia (NH3) and carbamate. A variety of urease inhibitors have been proposed to reduce NH3 volatilization by interfering with the urease activity. We report a quantum mechanics/
Shunya Suenaga, Yu Takano, Toru Saito
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Journal of Advanced Research, 2018 World population is expected to reach 9.7 billion by 2050, which makes a great challenge the achievement of food security. The use of urease inhibitors in agricultural practices has long been explored as one of the strategies to guarantee food supply in ...
Luzia V. Modolo +3 more
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A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria [PDF]
Journal of Advanced Research, 2018 Ureases are enzymes that hydrolyze urea into ammonium and carbon dioxide. They have received considerable attention due to their impacts on living organism health, since the urease activity in microorganisms, particularly in bacteria, are potential ...
Yuri F. Rego +6 more
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Natural Urease Inhibitors Reduce the Severity of Disease Symptoms, Dependent on the Lifestyle of the Pathogens [PDF]
Journal of Fungi, 2023 The development of new anti-ureolytic compounds is of great interest due to the newly discovered role of urease inhibitors in crop protection. Purine degradation and the generation of ammonium by urease are required for the full virulence of biotrophic ...
Lala Aliyeva-Schnorr +2 more
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Agriculture, 2022 Urea granule dissolution in soil and soil urease activity are essential parameters for the accurate prediction of nitrogen dynamics after urea application, but both are scarcely studied. The response of urease activity to temperature is unclear under the
Kang Ni, Andreas Siegfried Pacholski
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Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors [PDF]
Frontiers in ChemistryUrease, a nickel-dependent enzyme found in various life forms, catalyzes urea breakdown, concluding nitrogen metabolism by generating ammonia and carbamate.
Muhammad Akash +5 more
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Novel indole-based sulfonate and sulfamate derivatives as potent and selective urease inhibitors targeting Helicobacter pylori: a promising therapeutic strategy [PDF]
Gut PathogensHelicobacter pylori (H. pylori) infection is strongly associated with peptic ulcer and gastric cancer, compounded by the growing prevalence of antibiotic resistance.
Ghalia Khoder +12 more
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N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori.
Wei-Yi Li +11 more
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Screening and Identification of Herbal Urease Inhibitors Using Surface Plasmon Resonance Biosensor [PDF]
Research Journal of Pharmacognosy, 2021 Background and objectives: Urease, that catalyzes the hydrolysis of urea, has received substantial attention for its impact on living organisms’ health and human life quality.
Mahmood Biglar +6 more
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