Soil urease inhibition by various plant extracts. [PDF]
PLoS ONE, 2021 Urea is the most popular and widely used nitrogenous fertilizer. High soil urease activity rapidly hydrolyses applied urea to ammonia which contributes to soil nitrogen (N) losses and reduces N use efficiency of crop plants.
Muhammad Ajmal Rana +2 more
doaj +5 more sources
N-Arylacetamide derivatives of methyl 1,2-benzothiazine-3-carboxylate as potential drug candidates for urease inhibition [PDF]
Royal Society Open Science, 2023 Urease enzyme is an infectious factor that provokes the growth and colonization of virulence pathogenic bacteria in humans. To overcome the deleterious effects of bacterial infections, inhibition of urease enzyme is one of the promising approaches.
Sajila Hina +7 more
doaj +2 more sources
Synthesis, density functional theory (DFT) studies and urease inhibition activity of chiral benzimidazoles [PDF]
Heliyon, 2020 A variety of benzimidazole by the heterocyclization of orthophenylenediamine were synthesized in 69–86% yields. The synthesized compounds 3a-f and 6a-f were characterized and further investigated as jack bean urease inhibitors. Density functional theory (
Hasil Aman +5 more
doaj +2 more sources
An overview: metal-based inhibitors of urease
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Urease is a kind of nickel-dependent metalloenzyme, which exists in the biological world widely, and can catalyse the hydrolysis of urea into ammonia and carbon dioxide to provide a nitrogen source for organisms.
Wei Yang, Zhiyun Peng, Guangcheng Wang
doaj +2 more sources
Preparation, urease inhibition mechanisms, and anti-Helicobacter pylori activities of hesperetin-7-rhamnoglucoside [PDF]
Current Research in Microbial Sciences, 2022 This work investigated the effects of the bioflavonoid hesperetin-7-rhamnoglucoside isolated from Citrus uranium fruit peel on Helicobacter pylori (H. pylori). Separation and purity, crystalline state, and urease inhibition assays were carried out. Then,
Mohamed Sharaf +9 more
doaj +2 more sources
Synthesis, Urease Inhibition, Molecular Docking, and Optical Analysis of a Symmetrical Schiff Base and Its Selected Metal Complexes [PDF]
MoleculesDesigning and developing small organic molecules for use as urease inhibitors is challenging due to the need for ecosystem sustainability and the requirement to prevent health risks related to the human stomach and urinary tract.
Samuel Bonne +9 more
doaj +2 more sources
Bio-oriented synthesis of new sulphadiazine derivatives for urease inhibition and their pharmacokinetic analysis [PDF]
Scientific Reports, 2021 Current research is based on biology-oriented synthesis of sulphadiazine derivatives and determination of their urease inhibitory activity. In this regard, a series of (E)-4-(benzylideneamino)-N-(pyrimidin-2-yl)benzenesulfonamide was synthesized from ...
Asad Hamad +11 more
doaj +2 more sources
Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism. [PDF]
PLoS ONE, 2017 In this paper, we evaluated the anti-Helicobacter pylori activity and the possible inhibitory effect on its associated urease by Palmatine (Pal) from Coptis chinensis, and explored the potential underlying mechanism.
Jiang-Tao Zhou +10 more
doaj +2 more sources
Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses [PDF]
Molecules, 2019 The present study focuses on the design and synthesis of a cage-like organic skeleton containing two triazole rings jointed via imine linkage. These molecules can act as urease inhibitors.
Muhammad Hanif +9 more
doaj +2 more sources
Molecules, 2023 The development of novel scaffolds that can increase the effectiveness, safety, and convenience of medication therapy using drug conjugates is a promising strategy.
Saghir Ahmad +8 more
doaj +1 more source