Results 11 to 20 of about 678,840 (238)
An overview: metal-based inhibitors of urease
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Urease is a kind of nickel-dependent metalloenzyme, which exists in the biological world widely, and can catalyse the hydrolysis of urea into ammonia and carbon dioxide to provide a nitrogen source for organisms.
Wei Yang, Zhiyun Peng, Guangcheng Wang
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Urease activity according to the different inhibitors [PDF]
Anais da Academia Brasileira de Ciências, 2018 The objective of this study was to evaluate NBPT, zeolite and humic acid in different concentrations as inhibitors of the activity of the enzyme urease.
MATEUS P. GOMES +3 more
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Recent Advances in Design of New Urease Inhibitors: A Review [PDF]
Journal of Advanced Research, 2018 Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi. Bacterial enzyme is of special importance since it has been demonstrated as a potent virulence factor for some species.
Paweł Kafarski
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Catechol-based inhibitors of bacterial urease
Bioorganic & Medicinal Chemistry Letters, 2019 Targeted covalent inhibitors of urease were developed on the basis of the catechol structure. Forty amide and ester derivatives of 3,4-dihydroxyphenylacetic acid, caffeic acid, ferulic acid and gallic acid were obtained and screened against Sporosarcinia pasteurii urease.
Pagoni, A. +4 more
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Agronomic efficiency of NBPT as a urease inhibitor: A review
Journal of Advanced Research, 2018 Urea is the most widely used nitrogen (N) fertilizer, with a projected increase in annual demand of 1.5% in the coming years. After its application to soil, urea undergoes hydrolysis via the urease enzyme, causing increases in the soil pH in the ...
Heitor Cantarella +3 more
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Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials. [PDF]
PLoS Biology, 2018 Urease as a potential target of antimicrobial drugs has received considerable attention given its versatile roles in microbial infection. Development of effective urease inhibitors, however, is a significant challenge due to the deeply buried active site
Xinming Yang +7 more
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HeliyonUrease enzyme inhibition is a well-established and promising strategy for preventing the harmful effects of ureolytic bacterial infections, particularly those caused by H. pylori.
Hassan Sepehrmansourie +8 more
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Synergistic Effect of Urease and Nitrification Inhibitors in the Reduction of Ammonia Volatilization [PDF]
, 2021 Nitrogen (N) is deficient in more than 90% of soils of Pakistan mainly because of low organic matter contents. The use of nitrogenous fertilizers is a common practice for sustainable and profitable crop yields.
Hamza, Rafiq +7 more
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American Journal of Biotechnology and Bioscience, 2019 Urease, also known as urea amide hydrolase, contains two metal nickel ion active centers that catalyze the decomposition of urea to ammonia and carbon dioxide. Urease is widely found in nature, including plants, animals, and microorganisms, and greatly affects the utilization of nitrogen-containing nutrients by plants and animals. At the same time, its
Guan Zhou +3 more
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Monte-Carlo Method Based QSAR Model to Discover Phytochemical Urease Inhibitors Using SMILES and GRAPH Descriptors [PDF]
, 2020 We developed a Monte-Carlo method basedQSAR model to predict urease inhibiting potency of molecules using SMILES and GRAPHdescriptors on an existing diverse database of urease inhibitors.
Binata, Nayak +4 more
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