Results 101 to 110 of about 678,840 (238)

Urease inhibitors from Nasturtium officinale extract for the treatment of urease expressing bacterial infections

Urease is a virulence factor associated with Helicobacter pylori infections, catheter-associated urinary tract infections, and incontinence associated dermatitis.
Paul G Winyard (16226354), Rachel Heylen (24202902), Kyle Stewart (10864731), Emily Owen (18486005), Andrew Tobias A Jenkins (24414176)   +4 more
core   +3 more sources

Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors

, 2020
Urease is a therapeutic target associated with several important diseases and health problems. Based on our previous work on the inhibition of glucosidase and other enzymes and exploiting the privileged structure assigned to the (thio)barbiturate ...
M. Ali, Zaheer Ul-Haq, M. Iqbal Choudhary, Sammer Yousuf, Sajda Ashraf, Abdullah Mohammed Al-Majid, Ayman El-Faham, Fernando Albericio, Assem Barakat, Beatriz G. de la Torre   +9 more
core   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

, 2004
A computer-generated homology model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors.
Muri, Estela M.F., Stein, S. M., Mishra, Hetal, Williamson, John S.   +3 more
core   +1 more source

Herbivore and mesocarnivore carcasses trigger divergent short‐term changes in soil properties

Journal of Animal Ecology, EarlyView.
Scavengers reshape nutrient cycles in soils under carrion. Compared to herbivore carcasses, smaller but longer‐lasting carnivore remains boost nutrient levels and microbial activity in dry soils. Abstract Animal corpses act as pulses of organic matter (OM) and serve a key zoogeochemical role by providing localized nutrient inputs to soils and thereby ...
Adrián Colino‐Barea, Fuensanta García‐Orenes, Zebensui Morales‐Reyes, Moisés Gonzálvez, Carlos Martínez‐Carrasco, Marcos Moleón, Daniel Redondo‐Gómez, Evan A. N. Marks, Minerva García‐Carmona, Victoria Arcenegui, José Carlos Huerta‐del‐Bosque, Adrián Orihuela‐Torres, Santiago Soliveres, Sofia Albolafio, Esther Sebastián‐González, José Antonio Sánchez‐Zapata   +15 more
wiley   +1 more source

New Directions in Helicobacter pylori Urease Inhibitors: Focusing on Nickel Ions Transfer and Auxiliary Protein Interactions During Urease Maturation

Infection and Drug Resistance
Xinglan Chen, Lingzhu Gou, Yuanyuan Wang, Jinxia Yang, Yeze Dong, Baoyuan Xie, Dekui Zhang Key Laboratory of Digestive Diseases of Gansu Province, The Second Hospital of Lanzhou University, Lanzhou, 730030, People’s Republic of ChinaCorrespondence: Dekui
Chen X, Gou L, Wang Y, Yang J, Dong Y, Xie B, Zhang D   +6 more
doaj  

Synthesis, in vitro and in silico investigations of coumarin-benzamide hybrid molecules as urease inhibitors

Journal of Saudi Chemical Society
Enzymes play significant role in a variety of biochemical reactions. Urease is an enzyme that catalyzes the hydrolysis of urea into ammonia and carbamate.
Muhammad Shahid Nazir, Sumera Zaib, Matloob Ahmad, Sadia Sultan, Azhar Rasul, Muhammad Yaseen, Sami A. Al-Hussain, Magdi E. A. Zaki   +7 more
doaj   +1 more source

Stable flies preferentially oviposit on sites offering conspecific eggs with egg‐derived bacterial semiochemicals

Insect Science, EarlyView.
Stable flies preferentially oviposit on sites offering conspecific eggs with egg‐derived airborne semiochemicals. Egg‐borne bacterial symbionts, and Serratia marcescens in particular, produce odorants which attract gravid female flies and elicit oviposition.
Emmanuel Hung, Anya Gould, Stephanie Zaborniak, Caelen Watson, Regine Gries, Sukhmani Kaur, Kyra Stephens, Augustus Negraeff, Ryan Lam, Alpha Hui, Pantea Zamani, Aryan Monfared, Gerhard Gries   +12 more
wiley   +1 more source

Microbial CaCO3 precipitation for the production of biocement [PDF]

, 2004
The hydrolysis of urea by the widely distributed enzyme urease is special in that it is one of the few biologically occurring reactions that can generate carbonate ions without an associated production of protons. When this hydrolysis occurs in a calcium-
Whiffin, Victoria S.
core  

1,2-Benzisoselenazol-3(2H)‑one Derivatives As a New Class of Bacterial Urease Inhibitors

, 2016
Urease inhibitors are considered promising compounds for the treatment of ureolytic bacterial infections, particularly infections resulting from Helicobacter pylori in the gastric tract.
Ewa Grela (3068775), Ewa Rudzińska-Szostak (3068781), Monika Biernat (3068778), Jerzy Palus (2514421), Katarzyna Macegoniuk (446909), Agnieszka Grabowiecka (2276260), Łukasz Berlicki (1338477)   +6 more
core   +1 more source