Results 81 to 90 of about 52,663 (318)

Genital Crohn's disease in pediatrics and genetic associations

JPGN Reports, EarlyView.
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote ...
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak   +5 more
wiley   +1 more source

Development of a Mouse Model of Uremic Cardiomyopathy: Investigating the Impact of Chronic Kidney Disease on Cardiac Function and Signaling Pathway. [PDF]

FASEB J
Molecular changes in a mouse model of uremic cardiomyopathy. This model of 2,8‐DHA‐induced nephropathy in 129/Sv mice showed clinical features of uremic cardiomyopathy like reduced cardiac function and cardiac interstitial fibrosis and an unfavorable balance between protective and detrimental cardiac signaling.
Moellmann J, Glandien K, Klinkhammer BM, Wollenhaupt J, Noels H, Jankowski J, Lebherz C, Boor P, Lehrke M, Marx N.   +9 more
europepmc   +2 more sources

Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry : a pilot study [PDF]

, 2017
A typical characteristic of chronic kidney disease (CKD) is the progressive loss in renal function over a period of months or years with the concomitant accumulation of uremic retention solutes in the body.
Boelaert, Jente, Glorieux, Griet, Lynen, Frederic, Neirynck, Nathalie, Schepers, Eva, Vanholder, Raymond   +5 more
core   +1 more source

UREMIA [PDF]

Journal of the American Medical Association, 1916
When Bright noted an increase of urea in the blood and fluids of patients with severe nephritis and gave the name uremia to a group of symptoms likely to develop with these cases, he believed urea to be a highly toxic substance. The name uremia remains to us, although the term embraces now considerably more than urea intoxication.
openaire   +2 more sources

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

Design and Psychometric Properties of a Self-Care Questionnaire for the Elderly

Sālmand, 2015
Objectives: The purpose of this study was to design an Iranian cultural adaptable questionnaire for the assessment of self-care in the elderly. Methods & Materials: This methodological study was conducted in 2 phases. In the first phase, items&
Masomeh Hemmati Maslak Pak, Leila Hashemlo   +1 more
doaj  

Surgical Outcome of Peritoneal Dialysis in Elderly Patients

International Journal of Gerontology, 2009
Background: The success of peritoneal dialysis (PD) in elderly patients has been reported to be either slightly inferior or equivalent to that of younger patients.
Xin-Yi Ng, Chien-Liang Liu, Tsang-Pai Liu, Wen-Ching Ko, Shih-Ping Cheng, Chih-Jen Wu, Jie-Jen Lee   +6 more
doaj   +1 more source

Development and Validation of a Capillary Electrophoresis Coupled to Mass Spectrometry Pipeline for Comparable Assessment of the Plasma Peptidome

PROTEOMICS, EarlyView.
ABSTRACT Although capillary electrophoresis coupled to mass spectrometry (CE‐MS) holds promise for urinary peptide profiling, only a limited number of studies have used CE‐MS to study plasma peptides. Here we describe the establishment of a workflow, including sample preparation, CE‐MS analysis, data processing and normalization optimized for the ...
Lucie Fernandez, Benjamin Breuil, Carine Froment, Mouhamed Seye, Babacar Sylla, Marina Estanco, Adeline Chaubet, Eléonore Delecroix, Karima Chaoui, Jeanne Pierrette Vu, Serban Ardeleanu, Stanislas Faguer, Odile Burlet‐Schiltz, Bénédicte Buffin‐Meyer, Joost P. Schanstra, Julie Klein   +15 more
wiley   +1 more source

The quest for a better understanding of chronic kidney disease complications: an update on uremic toxins

Brazilian Journal of Nephrology, 2014
Chronic kidney disease is characterized by a progressive reduction of glomerular filtration rate and/or the appearance of proteinuria, and subsequently the progressive retention of organic waste compounds called uremic toxins (UT). Over the last decades,
Fellype Carvalho Barreto, Andréa Emilia Marques Stinghen, Rodrigo Bueno de Oliveira, Ana Tereza Barufi Franco, Andréa Novais Moreno, Daniela Veit Barreto, Roberto Pecoits-Filho, Tilman B. Drüeke, Ziad A. Massy   +8 more
doaj   +1 more source

Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease

PROTEOMICS, EarlyView.
ABSTRACT Naturally occurring fragments of collagen type I alpha 1 chain (COL1A1) have been previously associated with chronic kidney disease (CKD), with some fragments showing positive and others negative associations. Using urinary peptidome data from healthy individuals (n = 1131) and CKD patients (n = 5585) this aspect was investigated in detail ...
Ioanna K. Mina, Luis F. Iglesias‐Martinez, Matthias Ley, Lucas Fillinger, Paul Perco, Justyna Siwy, Harald Mischak, Vera Jankowski   +7 more
wiley   +1 more source