Results 161 to 170 of about 133,008 (211)
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The American Journal of Medicine, 1968
Urinary tract stones were known in prehistoric times. The oldest stone was unearthed in upper Egypt, dated approximately 4800 B.C. (Shattock, 1905). Stones have been discovered from Egyptian mummies of different dynasties (Miller, 1929; Wesson, 1935; Guthrie, 1946; Sigerist, 1951; Butt, 1956).
Alexander B. Gutman, Ts'ai-Fan Yü
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Urinary tract stones were known in prehistoric times. The oldest stone was unearthed in upper Egypt, dated approximately 4800 B.C. (Shattock, 1905). Stones have been discovered from Egyptian mummies of different dynasties (Miller, 1929; Wesson, 1935; Guthrie, 1946; Sigerist, 1951; Butt, 1956).
Alexander B. Gutman, Ts'ai-Fan Yü
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Annals of Internal Medicine, 1979
Excerpt To the editor: The article by Simkin and associates in the July issue (1) discussed a common problem in clinical medicine and provoked much conversation among the physicians here.
B K Jayaswal, C Greenberg
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Excerpt To the editor: The article by Simkin and associates in the July issue (1) discussed a common problem in clinical medicine and provoked much conversation among the physicians here.
B K Jayaswal, C Greenberg
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Current Hypertension Reports, 2006
Hyperuricemia is a frequent finding in diseases in which the clinical manifestations are thought to be secondary to a state of generalized vascular endothelial dysfunction and related to the cardiovascular disease present in conditions associated with the metabolic syndrome, such as hypertension or diabetes.
Michael L. Tuck, Dalila B. Corry
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Hyperuricemia is a frequent finding in diseases in which the clinical manifestations are thought to be secondary to a state of generalized vascular endothelial dysfunction and related to the cardiovascular disease present in conditions associated with the metabolic syndrome, such as hypertension or diabetes.
Michael L. Tuck, Dalila B. Corry
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1989
Uric acid is the end product of purine metabolism in humans. In animals other than mammals uric acid undergoes further degradation because of the activity of enzymes such as uricase, allantoinase and allantoinase; in some species the urea that is formed is further hydrolyzed to ammonia and CO2 by the urease of intestinal bacteria (1).
Fuiano G +3 more
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Uric acid is the end product of purine metabolism in humans. In animals other than mammals uric acid undergoes further degradation because of the activity of enzymes such as uricase, allantoinase and allantoinase; in some species the urea that is formed is further hydrolyzed to ammonia and CO2 by the urease of intestinal bacteria (1).
Fuiano G +3 more
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Urologic Clinics of North America, 2007
Uric acid nephrolithiasis may be the final manifestation of various pathophysiological processes. Recent advances in renal urate transport have elucidated mechanisms by which hyperuricosuria occurs. However, in most uric acid stone formers the primary pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria.
Mary Ann Cameron, Khashayar Sakhaee
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Uric acid nephrolithiasis may be the final manifestation of various pathophysiological processes. Recent advances in renal urate transport have elucidated mechanisms by which hyperuricosuria occurs. However, in most uric acid stone formers the primary pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria.
Mary Ann Cameron, Khashayar Sakhaee
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JAMA: The Journal of the American Medical Association, 1976
GOUTY arthropathy, urate lithiasis, and acute uric acid nephropathy may all complicate the course in a patient who has a malignant disease. All three problems originate from an increased uric acid turnover that occurs in this type of disease.
M C Perry, R D Wagoner, H C Hoagland
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GOUTY arthropathy, urate lithiasis, and acute uric acid nephropathy may all complicate the course in a patient who has a malignant disease. All three problems originate from an increased uric acid turnover that occurs in this type of disease.
M C Perry, R D Wagoner, H C Hoagland
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1989
Uric acid is the end-product of purine nucleotide metabolism in man. The renal handling of urate is a complicated process, resulting in a fractional clearance of 8.2-10.3%. The anhydrous form is thermodynamically the most stable uric acid crystal. Uric acid is a weak acid that ionizes with a Pka at pH 5.75.
A Halabe, Oded Sperling
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Uric acid is the end-product of purine nucleotide metabolism in man. The renal handling of urate is a complicated process, resulting in a fractional clearance of 8.2-10.3%. The anhydrous form is thermodynamically the most stable uric acid crystal. Uric acid is a weak acid that ionizes with a Pka at pH 5.75.
A Halabe, Oded Sperling
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Pediatric Nephrology, 2013
Uric acid, the end product of purine metabolism, is excreted predominantly by the proximal tubules. Abnormal serum levels of uric acid are due to alterations in production or excretion. Fractional excretion of uric acid is helpful in determining the underlying etiology of hypouricemia or hyperuricemia in children.
Monica T. Cramer, Sahar Fathallah-Shaykh
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Uric acid, the end product of purine metabolism, is excreted predominantly by the proximal tubules. Abnormal serum levels of uric acid are due to alterations in production or excretion. Fractional excretion of uric acid is helpful in determining the underlying etiology of hypouricemia or hyperuricemia in children.
Monica T. Cramer, Sahar Fathallah-Shaykh
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Current Opinion in Nephrology and Hypertension, 2003
The goal of this article is to review the physiology and describe newly defined molecular mechanisms that are responsible for renal urate transport.Four complementary DNAs have recently been cloned whose expressed proteins transport urate. Two of these proteins have been localized to the apical membrane of proximal tubular cells: one, a urate ...
Mohammed A Rafey +3 more
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The goal of this article is to review the physiology and describe newly defined molecular mechanisms that are responsible for renal urate transport.Four complementary DNAs have recently been cloned whose expressed proteins transport urate. Two of these proteins have been localized to the apical membrane of proximal tubular cells: one, a urate ...
Mohammed A Rafey +3 more
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Uric Acid Metabolism and Uric Acid Stones
2010Uric acid nephrolithiasis comprises 8–10% of patients with kidney stone disease. However, this prevalence is higher in particular ethnic populations and in certain regions of the world. The major pathophysiologic mechanism for uric acid nephrolithiasis is unduly acidic urine.
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