Results 11 to 20 of about 1,821 (152)

Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout.

open access: yesPLoS ONE, 2020
ObjectivesAlthough studies have demonstrated the association of hyperuricemia with cardiovascular (CV) diseases, few have explored the effect of urate-lowering therapy (ULT) on the incidence of CV diseases.
Fu-Shun Yen   +4 more
doaj   +1 more source

Various techniques for the evaluation of anti arthritic activity in animal models [PDF]

open access: yesJournal of Advanced Pharmaceutical Technology & Research, 2010
Arthritis is an auto immune disorder characterized by pain, swelling and stiffness. Its prevalence depends upon age. It occurs more frequently in women than in men. It is an inflammation of synovial joint due to immuno mediated response.
Shivanand Pandey
doaj   +1 more source

Plasmablastic Lymphoma of the Kidney in a Previously Undiagnosed HIV Patient

open access: yesMarshall Journal of Medicine, 2021
We present the case of a 61-year-old male who presented with flank pain and dysuria. A biopsy and histopathological analysis of a mass found in the left kidney led to the diagnosis of plasmablastic lymphoma (PBL).
Amrita Valluri   +4 more
doaj   +1 more source

Effects of urate-lowering agents on arrhythmia vulnerability in post-infarcted rat hearts

open access: yesJournal of Pharmacological Sciences, 2016
Hyperuricemia has been shown to be associated with ventricular arrhythmias. However, the mechanisms remained unknown. We assessed whether different urate-lowering agents can attenuate arrhythmias through lowering urate itself or inhibiting xanthenes ...
Tsung-Ming Lee   +2 more
doaj   +1 more source

Bipartite patella associated with tophaceous invasion: A rare case report

open access: yesJournal of Medical Sciences, 2017
We report the case of 32-year-old male who had a painful knee due to tophus formation in the interosseous area of the bipartite patella. There was neither a history of previous trauma to his patella nor a family history of gouty arthritis ...
Kuo-Chien Chang   +3 more
doaj   +1 more source

Photoinduced Selective Construction of Densely Functionalized Spirocyclic Ethers With Carbyne Equivalents

open access: yesAngewandte Chemie, EarlyView.
A reactivity programmed cascade between carbyne equivalents and allylic benzoates was developed that sequentially orchestrates all three reactivity modes of carbyne equivalents, enabling the rapid installation of three σ‐bonds at a single carbon center and providing efficient, scalable access to structurally diverse spirocyclic ethers. ABSTRACT Carbyne
Jianke Su   +5 more
wiley   +2 more sources

Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout

open access: yesScientific Reports, 2017
Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. Here, we characterize verinurad (RDEA3170), which is currently under evaluation for gout therapy.
Philip K. Tan   +3 more
doaj   +1 more source

The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone.

open access: yesPLoS ONE, 2012
Eyes Absents (EYA) are multifunctional proteins best known for their role in organogenesis. There is accumulating evidence that overexpression of EYAs in breast and ovarian cancers, and in malignant peripheral nerve sheath tumors, correlates with tumor ...
Emmanuel Tadjuidje   +5 more
doaj   +1 more source

Comparative evaluation of uricodepressants allopurinol and febuxostat in gouty nephropathy. Message 1. Сlinical study

open access: yesPočki, 2018
Background. Renal damage is an almost constant symptom of gout, which determines the prognosis of the dise­ase. Hyperuricemia in gouty nephropathy belongs to independent risk factors for deterioration of the nitrogen and electrolyte excretory function of
D.D. Ivanov   +3 more
doaj   +1 more source

Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine

open access: yesBMC Complementary and Alternative Medicine, 2019
Background Prolonged hyperuricemia is associated with kidney disease or gouty arthritis. Whether Yokuininto, a commercially available Kampo medicine that has been used for osteoarthritis or rheumatoid arthritis, can exhibit anti-hyperuricemic and ...
Seung Hoon Lee   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy