Results 41 to 50 of about 2,933 (228)

Probenecid Blocks Human P2X7 Receptor-Induced Dye Uptake via a Pannexin-1 Independent Mechanism [PDF]

, 2014
P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
A Piccini, A Pupovac, A Surprenant, A Takahashi, AD Michel, AN Shemon, AN Shemon, Archana Bhaskaracharya, AVP Alberto, C Marques-da-Silva, C McClenaghan, D Ferrari, D Khanna, F Di Virgilio, F Martinon, F Martinon, F Roch-Ramel, Iman Jalilian, J Schachter, JH Tao, JS Wiley, Kristen K. Skarratt, L Stokes, Leanne Stokes, Mari Spildrejorde, N Riteau, P Pelegrin, P Pelegrin, Phuong Dao-Ung, PJ Hanley, R Bartlett, R Sluyter, R Sluyter, RG Deeley, Ronald Sluyter, S Bang, S Gadeock, SR Kingsbury, Stephen J. Fuller, Steven Barnes, TA Greene, TD Kanneganti, TH Steinberg, W Ma, W Silverman, Y Qu   +45 more
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The effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on serum uric acid levels in adult patients with arterial hypertension: A systematic review

Рациональная фармакотерапия в кардиологии
Aim. To summarize the available data on the effects of first-line antihypertensive agents – angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) – on serum uric acid (UA) levels in adults with (arterial ...
T. E. Morozova, A. V. Volnukhin, A. V. Vlasova, E. O. Samokhina, A. V. Manzyuk, A. A. Gertsog, N. V. Shikh   +6 more
doaj   +1 more source

Epidemiology and management of gout in Taiwan: a nationwide population study [PDF]

, 2015
INTRODUCTION: Gout is the most common inflammatory arthritis worldwide and is the only type of chronic arthritis that potentially can be ‘cured’. However, data on gout incidence, prevalence and management, assessed at multiple time points in the same ...
Doherty, Michael, Grainge, Matthew J., Kuo, Chang-Fu, Luo, Shue-Fen, See, Lai-Chu, Yu, Kuang-Hui, Zhang, Weiya   +6 more
core   +1 more source

Acute and Subacute Oral Toxicity Evaluation of Baccaurea motleyana Fruit Extract in Wistar Rats

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Baccaurea motleyana fruit exhibited no significant toxic effects in Wistar rats, as evidenced by hematological and biochemical analyses. Moreover, histopathological evaluation of the liver and kidney revealed no detectable abnormalities. ABSTRACT Baccaurea motleyana (Rambai) is traditionally consumed in Southeast Asia and used ethnomedicinally, yet its
Md. Mahmudul Hasan, Eftekhar Alam Bhuyan, Md. Ekramul Haque Ekram, Nawreen Monir Proma, Mohammed Kamrul Hossain   +4 more
wiley   +1 more source

Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout. [PDF]

, 2019
ObjectiveLesinurad (LESU) is a selective urate reabsorption inhibitor approved at 200 mg daily for use with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in gout patients failing to achieve target serum urate on XOI. The aim of the study was
Baumgartner, Scott, Goldfarb, David S, Jalal, Diana, Pillinger, Michael, Saag, Kenneth G, Schechter, Bruce M, Terkeltaub, Robert, Valiyil, Ritu, White, William B   +8 more
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Daidzein Ameliorate Hyperuricemia by Upregulating ABCG2 Expression via Activation of PPARγ and PI3K/AKT Pathways

Food Frontiers, Volume 7, Issue 2, March 2026.
Hyperuricaemia is a chronic metabolic disorder arising from impaired purine metabolism, exhibiting marked gender disparities in its prevalence. Daidzein, possessing oestrogen‐like effects, promotes uric acid excretion and improves hepatic and renal function, thereby presenting potential utility as an adjunctive therapeutic agent for hyperuricaemia ...
Zicheng Zhu, Jujie Pan, Ruixia Bao, Beibei Chen, Siyi Li, Ziyu Che, Qian Chen, Yuzheng Wu, Dan Wang, Tao Wang   +9 more
wiley   +1 more source

POS1130 PHARMACOKINETICS AND SERUM URATE LOWERING EFFECTS OF AR882, A NOVEL, POTENT AND SELECTIVE URICOSURIC AGENT, IN PATIENTS WITH GOUT [PDF]

, 2021
Ziyi Shen, E. Polvent, V. Hingorani, Ana Roche, Carol A. Colton, Ru Yan, Shushan Yan, Li‐Tain Yeh   +7 more
openalex   +1 more source

Long‐term remission in gout: Challenges and future opportunities

Rheumatology &Autoimmunity, Volume 6, Issue 1, Page 7-15, March 2026.
Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley   +1 more source

Guideline development for the management of gout: role of combination therapy with a focus on lesinurad

Drug Design, Development and Therapy, 2017
Graeme Jones,1 Elena Panova,1 Richard Day2 1Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia; 2University of New South Wales, Medicine, St Vincent’s Hospital, Sydney, NSW, Australia Abstract: The aim of this ...
Jones G, Panova E, Day R
doaj  

Volume Five Subject Index [PDF]

, 1969
Subject index for MCV/Q, Medical College of Virginia Quarterly, Volume ...

core   +1 more source