Results 51 to 60 of about 2,933 (228)

A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction [PDF]

, 2023
Jian Gao, Hao Yin, Yanqun Dong, Xintong Wang, Yani Liu, KeWei Wang   +5 more
openalex   +1 more source

Anti‐Arthritic Potential of Pyrazoline Derivative Against Complete Freund's Adjuvant Induced Arthritis in Rats

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT This research explored the potential of a synthesised pyrazoline derivative 5‐ethoxy 5‐hydroxy 3‐methyls 4, 5‐dihydro 1Hpyrazol 1 yl (pyridine 4 yl) methanone [5‐E‐5‐H‐PD], against arthritis using a Complete Freund's Adjuvant (CFA)‐induced arthritis in a rat model.
Jian Li, Irfan Anjum, Halima Qadir, Faiza Naseer, Mehreen Arif, Muhammad Riaz, Rabia Gul, Madiha Kanwal, Bei Zhuang   +8 more
wiley   +1 more source

The Role of Helicobacter pylori in Peptic Ulcer Disease [PDF]

, 1993
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90299/1/j.1875-9114.1993.tb02740.x ...
Partipilo, Maria L., Woster, Patricia S.
core   +1 more source

Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double‐Blind, Phase 3 Trial in China

Arthritis &Rheumatology, Volume 77, Issue 12, Page 1757-1766, December 2025.
Objective Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicenter, randomized, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad ...
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Urate Handling in the Human Body [PDF]

, 2016
Elevated serum urate concentration is the primary cause of gout. Understanding the processes that affect serum urate concentration is important for understanding the etiology of gout and thereby understanding treatment. Urate handing in the human body is
David Hyndman, Jeffrey N. Miner, Sha Liu
core   +1 more source

The last defence? Surgical aspects of gouty arthritis of hand and wrist [PDF]

, 2011
OBJECTIVE: To review the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of gouty arthritis of the hand and wrist, with a focus on the surgical aspects. DATA SOURCES AND EXTRACTION: Electronic databases including MEDLINE,
Fung, BKK, Tang, CKY
core  

Allopurinol Versus Febuxostat Use and the Risk of Cardiovascular Disease in People With Chronic Kidney Disease: A New‐User Active Comparator Cohort Study

Nephrology, Volume 30, Issue 11, November 2025.
This retrospective cohort study assessed the cardiovascular outcomes in people with chronic kidney disease who were newly prescribed allopurinol or febuxostat. ABSTRACT Aim Hyperuricaemia, a common comorbidity among people with chronic kidney disease, is widely treated with uric acid‐lowering agents such as allopurinol and febuxostat.
Reiko Inoue, Satoko Yamaguchi, Akira Okada, Toshimasa Yamauchi, Takashi Kadowaki, Masaomi Nangaku   +5 more
wiley   +1 more source

CD40LG as a Biomarker in Rheumatoid Arthritis: Links to Bone Destruction and Interstitial Lung Disease ‐ A Bioinformatic Analysis With Clinical Validation

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Biomarkers are essential tools in the diagnosis and management of various diseases. Rheumatoid arthritis (RA) is a systemic inflammatory disorder that frequently results in damage to joints and organs. Here, we examined potential biomarkers and therapeutic agents for RA patients.
Chuanhui Yao, Hui Xu, Xun Gong, Xieli Ma, Yuchen Yang, Dan Dou, Qiuwei Peng, Juan Jiao, Xiaopo Tang, Quan Jiang, Congmin Xia   +10 more
wiley   +1 more source

Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement [PDF]

, 2016
Background: Recently published guidelines on the medical management of renal stone disease did not address relevant topics in the field of idiopathic calcium nephrolithiasis, which are important also for clinical research.
Bartoletti, R., Buchholz, N., Buchholz, N.N.-P. (Noor), Bushinsky, D., Bushinsky, D. (David), Capasso, G.B., Cicerello, E., Coe, F., Coe, F. (Fredric), Croppi, E. (Emanuele), Cupisti, A., Curhan, G.C., Curhan, G.C. (Gary C.), Desai, J., Fabris, A., Ferraro, P.M., Ferraro, P.M. (Pietro Manuel), Fuster, D., Fuster, D. (Daniel), Gambaro, G., Gambaro, G. (Giovanni), Goldfarb, D.S., Goldfarb, D.S. (David S.), Heilberg, I.P., Heilberg, I.P. (Ita Pfeferman), Hess, B., Hess, B. (Bernhard), Jaeger, P. (Ph), Kirkali, Z. (Ziya), Kok, D.J. (Dirk), Letavernier, E., Lieske, J., Lieske, J. (John), Lingeman, J., Lingeman, J. (James), Marangella, M., Marangella, M. (Martino), Mazzaferro, S., Milliner, D., Milliner, D. (Dawn), Moe, O., Moe, O. (Orson), Nouvenne, A., Preminger, G.M., Preminger, G.M. (Glen M.), Prie, D., Reis Santos, J., Reis Santos, J.M. (Jose’ Manuel), Rendina, D., Sakhaee, K. (Khashayar), Sarica, K., Sarica, K. (Kemal), Siener, R., Siener, R. (Roswitha), Soldati, L., Strazzullo, P., Strazzullo, P. (Pasquale), Tasca, A., Trinchieri, A., Vezzoli, G., Vitale, C., Williams, J.C., Williams, J.C. (James C.), Worcester, E., Worcester, E. (Elen), Wu, W.   +65 more
core   +3 more sources

Silent Dangers in Elderly Pharmacotherapy: The Interplay of Polypharmacy, Multimorbidity, and Drug Interactions

Journal of Evaluation in Clinical Practice, Volume 31, Issue 7, October 2025.
ABSTRACT Background Pharmacological therapy in older persons is inherently complex due to the interplay of age‐related physiological changes, multimorbidity, and polypharmacy. These factors increase the vulnerability of elderly patients to drug interactions and adverse drug reactions.
N. N. Ngcobo
wiley   +1 more source