Results 61 to 70 of about 2,933 (228)
Arthritis Care &Research, Volume 77, Issue 9, Page 1149-1156, September 2025.Objective The objective of this study was to evaluate and compare the risk of hepatotoxicity associated with the use of febuxostat and benzbromarone in patients with gout. Methods New users of febuxostat or benzbromarone with monitoring of liver function at least three times in a year after initiation of the study drugs were identified from an ...
Wenyan Sun +8 more
wiley +1 more source
Connexins and pannexins: from biology towards clinical targets. [PDF]
, 2016 Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the ...
Haefliger, J.A., Meda, P.
core +1 more source
Gout in pediatric renal transplant recipients [PDF]
, 2018 Clinical gout has rarely been described after pediatric renal transplantation (RTx), although asymptomatic hyperuricemia is common in these patients. We describe three male pediatric patients who presented with gouty arthritis 7-8.5 years following RTx ...
Goetschel, Philippe +3 more
core
Journal of Diabetes Investigation, Volume 16, Issue 9, Page 1733-1741, September 2025.High uric acid (UA) facilitates diabetes progression and is responsible for developing other diseases, such as cardiovascular disease and renal disease. Lifestyle modifications could lower UA levels, but relevant evidence is required in patients with type 2 diabetes.
Jie Li, Ertao Zhang, Zhao Dong, Yan Liu
wiley +1 more source
Advances in Xanthine Oxidase Inhibition: A Review of Potential Bioactive Synthetic Compounds
Archiv der Pharmazie, Volume 358, Issue 8, August 2025.This review article looks at new synthetic xanthine oxidase inhibitors discovered in the last 5 years (2025–2020). It covers an analysis of the advances, structural diversity, biological potential of the molecules investigated and future prospects in drug development.
Giorgio Antoniolli +4 more
wiley +1 more source
A pilot study of IL-1 inhibition by anakinra in acute gout [PDF]
, 2007 Monosodium urate crystals stimulate monocytes and macrophages to release IL-1β through the NALP3 component of the inflammasome. The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes with mutations in the NALP3 protein suggested ...
Alexander So +20 more
core +3 more sources
European Journal of Heart Failure, Volume 27, Issue 8, Page 1472-1478, August 2025.Effects of empagliflozin on uric acid levels during acute heart failure recompensation. Abstract Background Sodium–glucose cotransporter 2 inhibitors improve prognosis in chronic heart failure as part of currently recommended therapeutic strategies.
Jurgen Bogoviku +7 more
wiley +1 more source
Management of hyperuricemia in gout: focus on febuxostat
Clinical Interventions in Aging, 2010 Mattheus K Reinders1, Tim L Th A Jansen21Clinical Pharmacy, Atrium Medisch Centrum Parkstad, Heerlen, The Netherlands; 2Rheumatology, Medisch Centrum Leeuwarden, Leeuwarden, The NetherlandsAbstract: Gout is the most common inflammatory arthritis in an ...
Mattheus K Reinders, Tim L Th A Jansen
doaj
Association of serum uric acid with proteinuria in type 2 diabetic patients [PDF]
, 2013 Background: Various findings suggest that uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy.
Baradaran, A. +3 more
core +3 more sources
International Journal of Rheumatic Diseases, Volume 28, Issue 8, August 2025.ABSTRACT Objective The aim of this updated guideline is to provide comprehensive recommendations for the management of gout in patients with common comorbidities, such as chronic kidney disease (CKD), cardiovascular disease (CVD), diabetes, osteoarthritis (OA), and gastrointestinal disorders.
Changgui Li +30 more
wiley +1 more source