Results 211 to 220 of about 134,815 (339)

Proximity‐Induced Ligation of Noncomplementary Oligonucleotides Triggered by Charge‐Transfer Interactions

ChemistryEurope, Volume 4, Issue 1, January 2026.
Charge‐transfer assisted ligation (CTAL) enables ultrafast CuAAC and SPAAC conjugation of a tetra‐DiAlkoxyNaphthalene (DAN4)‐azide and a noncomplementary tetraNaphthaleneDiImide (NDI4)‐alkyne oligonucleotide under dilute conditions, and the reaction can be carried out tracelessly by subsequently removing the tags.
Laura Nicollet, Kévan Pérez de Carvasal, Nessrine Graidia, François Morvan, Michael Smietana   +4 more
wiley   +1 more source

Uridine as a hub in cancer metabolism and RNA biology. [PDF]

Exp Mol Med
Choi KM, Berard BA, Yoon JH, Kim D.
europepmc   +1 more source

Challenges and Limitations of Sequential MET‐TKI Therapy in METex14‐ Positive NSCLC With a Focus on Non‐ILD Toxicities: A Case Report

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background Nonsmall cell lung cancer (NSCLC) with mesenchymal‐epithelial transition exon 14 skipping mutation (METex14) represents a distinct molecular subtype with limited therapeutic options. Selective MET tyrosine kinase inhibitors (MET‐TKIs) such as tepotinib, capmatinib, and gumarontinib have improved outcomes, but toxicities frequently ...
Akina Nigi, Toshikazu Kumasa, Keisuke Iwamoto, Hidetoshi Itani, Shigeto Kondou, Junji Uraki   +5 more
wiley   +1 more source

Discovery of α-glucosidase inhibitors from Paenibacillus sp. JNUCC 31 via genome mining, fatty acid profiling, and in silico analysis. [PDF]

Sci Rep
Xu Y, Liang X, Hyun CG.
europepmc   +1 more source

Studies on glucuronic acid metabolism: effect of uridine diphosphate glucuronic acid and thiol groups on the enzymes in the glucuronic acid metabolism series

, 1974
Shunkichi TAMURA, Shintaro Tsuzuki, Reiko Mizukami, Izumi Tanaka, Yoshito Matsumoto   +4 more
openalex   +1 more source

Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation

, 2021
Eduardo R. Lazarowski, László Homolya, Richard C. Boucher, T. Kendall Harden   +3 more
openalex   +1 more source

A Phase 1 Dose‐Escalation, Food Effect, and Drug–Drug Interaction Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MALT1 Inhibitor, SGR‐1505, in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract SGR‐1505 is a novel small‐molecule inhibitor of MALT1, a key mediator of NF‐κB signaling implicated in the pathogenesis of B‐cell malignancies. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of SGR‐1505 in healthy volunteers. In this four‐part, open‐label study, 73 participants received single or multiple
Vipul K. Gupta, Brian Yoo, Daniel Weiss, Frank G. Basile, Edgar Schuck, Christopher M. Rubino, Sen Zhang, Stephen E. Maxwell, Wenxin Zheng, Joanne B. L. Tan, David Stenehjem, Paul B. Watkins, Margaret Dugan, Wu Yin, D. Hamish Wright, Karen Akinsanya, Jason Lickliter   +16 more
wiley   +1 more source

Potentiometric and spectroscopic characterization of uridine and its derivatives complexes. [PDF]

Sci Rep
Stachowiak K, Zabiszak M, Teubert A, Jastrząb R.   +3 more
europepmc   +1 more source

The wobble hypothesis revisited: Uridine-5-oxyacetic acid is critical for reading of G-ending codons [PDF]

, 2007
Joakim Näsvall, Peng Chen, Glenn R. Björk   +2 more
openalex   +1 more source

Ryanodine‐1‐Calstabin Complex Stabilizers in Antidoping Research: Synthesis, Metabolism, and Characterization

ChemPlusChem, Volume 91, Issue 1, January 2026.
RYR‐stabilizers such as S107, JTV‐519, ARM 036, and ARM 210 are emerging doping‐relevant compounds due to their performance‐enhancing effects on leaky skeletal muscle Ca2+ channels. To support proactive antidoping efforts, all four compounds were synthesized and their in vitro metabolism was systematically investigated.
Tristan Möller, Thomas Piper, Mario Thevis   +2 more
wiley   +1 more source