Metabolic responses to benzoic acid stress and glutamine transport-dependent vulnerabilities in Escherichia coli revealed by NMR metabolomics. [PDF]
Öztürkel-Kabakaş H +7 more
europepmc +1 more source
ABSTRACT Omics biomarkers comprise several molecular entities, including genomic, epigenomic, transcriptomic, proteomic, and metabolomic signatures. They play an essential role in oncology drug development and clinical settings by enabling personalized medicine.
Mai Mehanna +8 more
wiley +1 more source
Association between 1400 blood metabolites and the risk of ankylosing spondylitis: A 2-stage, 2-sample Mendelian randomization study. [PDF]
Li F, Zhou X, Li C, Zhang Z, Yang Q.
europepmc +1 more source
Abstract Introduction Two‐drug regimens (2DRs) may reduce long‐term drug toxicities and drug‐drug interactions for people with HIV (PWH) on antiretroviral therapy (ART). This study evaluated clinical and laboratory outcomes in PWH who switched from standard ART to dolutegravir and lamivudine (DTG + 3TC) in real‐world settings.
Tommy Hing‐cheung Tang +15 more
wiley +1 more source
Integrated transcriptomic and metabolomic analyses reveal the ABC transporter-related genes and metabolites involved in seed aging of Platostoma palustre (Blume) A. J. Paton. [PDF]
Tang D, Li J, Quan C, Xu M, Wei F.
europepmc +1 more source
ABSTRACT Microorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses.
Pedro Igor Zocateli +12 more
wiley +1 more source
Plasma metabolomics reveals distinct responses to acute and chronic heat stress in broilers. [PDF]
Papanikolaou A +6 more
europepmc +1 more source
ABSTRACT Salinity combined with waterlogging is a major abiotic stress that severely limits crop growth and yield. We investigated species‐specific adaptations to salinity under constant waterlogging conditions in the wild halophytic barleys Hordeum marinum and H. glaucum, compared with the cultivated H. vulgare.
Stanislav Isayenkov +10 more
wiley +1 more source
Crystal structure of epidermal growth factor domain-specific <i>O</i>-linked <i>N</i>-acetylglucosamine transferase reveals a conserved N-R-R constellation for uridine diphosphate recognition in the GT61 family. [PDF]
Tashima Y, Nagae M, Jiang J, Okajima T.
europepmc +1 more source
Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis
SUMMARY In plants, nucleotide de novo synthesis is required throughout development to provide building blocks for the synthesis of DNA, RNA and nucleotide‐derived cofactors. Inosine Monophosphate Dehydrogenases (IMPDH) are key enzymes in de novo guanylate synthesis.
Eva Dörfer +10 more
wiley +1 more source

