Results 191 to 200 of about 74,197 (237)

Synthesis of 4'-C-α-Aminoethoxy-2'-O-Methyl-5-Methyl- and 5-Propynyl-Uridine Phosphoramidites for Structurally Optimized Antisense Oligonucleotides. [PDF]

Curr Protoc
Mahmoud EM, Ueno Y.
europepmc   +1 more source

Age‐related differences in mRNA vaccine immunogenicity and adjuvancy

Immunology &Cell Biology, Volume 104, Issue 4, Page 400-414, April 2026.
Older people often respond poorly to mRNA vaccines, with reduced T and B cell responses, but they also bear more morbidity and mortality for infectious diseases. This paper maps age‐related changes in mechanisms of adjuvancy that can shape the immunogenicity of mRNA vaccine in a mouse model. Created in BioRender.
Shivali Savita Chinni, Gemma S Trollope, Patrick Leung, Jonathan L McQualter, Chee Wah Tan, Linfa Wang, Leonard Lim, Adam K Wheatley, Jennifer A Juno, Stephen J Kent, Hareth A Al‐Wassiti, Colin W Pouton, Kylie M Quinn   +12 more
wiley   +1 more source

From Amphiphiles to mRNA platforms: emerging vaccination strategies for pancreatic cancer. [PDF]

Exp Hematol Oncol
Lee DG, Noh K.
europepmc   +1 more source

Inactivation of CDK12 Enhances Mitochondrial Efficiency to Suppress DNA Damage

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Inactivation of cyclin‐dependent kinase 12 (CDK12) characterizes a subset of prostate cancers but it is not understood how cells adapt to declining activity of this major transcription elongation kinase. To probe this response, we developed a cell line resistant to an inhibitor targeting CDK12 and its paralog, CDK13.
Aishwarya Gondane, Shivani Yalala, Jing Liang, Sonja Saira, Harri M. Itkonen   +4 more
wiley   +1 more source

Longitudinal characterization of mature beef bull seminal fluid and blood serum metabolome during a 65-day breeding season. [PDF]

Transl Anim Sci
Williams JD, Crouse MS, La Frano MR, Campos-Chillòn LF, Cunningham-Hollinger HC, Field CE, McFarlane ZD.   +6 more
europepmc   +1 more source

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, Volume 24, Issue 4, Page 1936-1949, April 2026.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

[Determination of uridine-5'-triphosphate, uridine-5'-diphosphate, uridine-5'-monophosphate and uridine by ion exchange chromatography separation and spectrophotometric analysis].

Annali dell'Istituto superiore di sanita, 1969
P, Betto, L, Longinotti
openaire   +1 more source

To modify or not to modify: Rethinking mRNA design for CAR T cell engineering. [PDF]

Mol Ther Nucleic Acids
Thatte AS, Mitchell MJ.
europepmc   +1 more source

Screening of purine nucleoside analogues against intracellular Toxoplasma gondii. [PDF]

Int J Parasitol Drugs Drug Resist
Elati HAA, Van Calenbergh S, Sheiner L, de Koning HP.   +3 more
europepmc   +1 more source

ATP-related purinergic signaling via P2Y12 contributes to airway epithelial barrier integrity. [PDF]

BMC Mol Cell Biol
Tsuya K, Maruoka S, Okamoto S, Shikano S, Ujike M, Yamada S, Kurosawa Y, Mizumura K, Kozu Y, Gon Y.   +9 more
europepmc   +1 more source