Results 181 to 190 of about 74,197 (237)

Uridine-cytidine kinase 2 as a novel potential prognostic and therapeutic biomarker in gastric cancer. [PDF]

Transl Cancer Res
Sun W, Guo H, Cai M, Ma G, Zhang L, Yu Y, Zhan H.   +6 more
europepmc   +1 more source

A TLR8 Variant Identified From Whole Exome Sequencing as a Sepsis‐Prone Mutation

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
Whole‐exome sequencing of sepsis patients identified a recurrent high‐impact TLR8 rs3764880 variant enriched in bacterial sepsis. Single‐cell transcriptomics localized elevated TLR8 expression to non‐classical monocytes, while bulk RNA‐seq and functional assays demonstrated enhanced IFN‐β responses following TLR8 stimulation.
Fahd Alhamdan, Stefano Gianoli, Xioahui Han, Sophia Koutsogiannaki   +3 more
wiley   +1 more source

Uridine as a hub in cancer metabolism and RNA biology. [PDF]

Exp Mol Med
Choi KM, Berard BA, Yoon JH, Kim D.
europepmc   +1 more source

Structures of pentatricopeptide repeat proteins

Acta Crystallographica Section F, Volume 82, Issue 4, Page 101-113, April 2026.
A number of crystal, cryo‐EM and solution structures of pentatricopeptide repeat proteins have been solved, revealing details of how they interact with single‐stranded RNA and other proteins, as well as their conformational repertoire.Pentatricopeptide repeat (PPR) proteins constitute the largest family of RNA‐binding proteins in land plants, playing ...
Anuradha Pullakhandam, Crystal Cooper, Ian D. Small, Charles S. Bond   +3 more
wiley   +1 more source

Discovery of α-glucosidase inhibitors from Paenibacillus sp. JNUCC 31 via genome mining, fatty acid profiling, and in silico analysis. [PDF]

Sci Rep
Xu Y, Liang X, Hyun CG.
europepmc   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Potentiometric and spectroscopic characterization of uridine and its derivatives complexes. [PDF]

Sci Rep
Stachowiak K, Zabiszak M, Teubert A, Jastrząb R.   +3 more
europepmc   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

C‑Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2'-OH. [PDF]

ACS Cent Sci
Banerjee D, Xiao L, Thacker PS, Kundu J, Manoharan M, Kool ET.   +5 more
europepmc   +1 more source

Population Pharmacokinetic Model Assessment of the Effects of Body Weight on Risk of Drug–Drug Interactions After Posaconazole Discontinuation

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Posaconazole is a broad‐spectrum triazole antifungal agent indicated for the prophylaxis and treatment of invasive fungal infections. Posaconazole pharmacokinetics and drug–drug interactions (DDIs), due to cytochrome P450 3A4 (CYP3A4) inhibition, have been previously characterized.
Rebecca E. Wrishko, Thomas J. Bateman, Matthew G. Johnson, Prajakti A. Kothare   +3 more
wiley   +1 more source