Results 161 to 170 of about 74,197 (237)

mRNA-based CAR T cell engineering: Unmodified mRNA enables high CAR expression without innate immune activation in T cells. [PDF]

Mol Ther Nucleic Acids
Kahwaji N, Kotzian N, Prinz JM, Pu Y, Kath J, Picht S, Hiller AL, Klaas A, Dunne CM, Launspach M, Palmowski A, Kleyer A, Simon DN, Wagner DL, Pichon C, Krönke G, Schmueck-Henneresse M, Volk HD, Gossen M, Drzeniek NM.   +19 more
europepmc   +1 more source

Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao Zhang   +4 more
wiley   +1 more source

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis. [PDF]

Nat Metab
Strefeler A, Baker ZN, Chollet S, Foged MM, Guerra RM, Ivanisevic J, Gallart-Ayala H, Pagliarini DJ, Jourdain AA.   +8 more
europepmc   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, Volume 4, Issue 4, April 2026.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Selective DNA encapsulation in extracellular vesicles of <i>Saccharomyces cerevisiae</i>. [PDF]

Extracell Vesicles Circ Nucl Acids
Perea-Martínez A, Mejías-Ortiz M, Morales P, Gonzalez R.   +3 more
europepmc   +1 more source

Teriflunomide Attenuates Demyelination and Enhances Remyelination in Organotypic Brain Slice Cultures Through Modulation of Glial Cell Dynamics

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
In an organotypic cerebellar slice culture (OSC) ex vivo demyelination model, teriflunomide has been shown to positively affect myelin preservation during demyelination and enhance remyelination. This is hypothesized as being achieved by modulating the dynamics of glial cells.
Jessica Kronenberg, Lara‐Jasmin Schröder, Henriette Reinsberg, Thomas Skripuletz, Sandra Heckers, Florian Hansmann, Wolfgang Baumgärtner, Martin Stangel, Viktoria Gudi   +8 more
wiley   +1 more source

Effects of Cedirogant on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates

Clinical Pharmacology in Drug Development, Volume 15, Issue 4, April 2026.
Abstract This study aimed to characterize the effects of cedirogant, an inverse agonist of retinoic acid–related orphan receptor gamma thymus (RORγt), on activities of cytochrome P450 (CYP) enzymes in healthy adults. Twenty study participants received a single oral dose of the modified Cooperstown 5+1 cocktail CYP probe drugs alone without cedirogant ...
Ronilda D'Cunha, Yuli Qian, Shuai Hao, Jason Eccleston, Gweneth F. Levy, Shashikanth Gannu, David G. Rizzo, Wei Liu, Mohamed‐Eslam F. Mohamed   +8 more
wiley   +1 more source

Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes. [PDF]

Proc Natl Acad Sci U S A
Chakraborty J, Ghosh A, Awuah EB, Stabler SP, Field MS, Bailey RL, Stover PJ.   +6 more
europepmc   +1 more source

Da Yuan Yin Regulates Gut Microbiota and Improves Intestinal Injury in Sepsis

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Sepsis mouse model was induced by LPS to investigate the effect of Da Yuan Yin (DYY) in vivo. Hematoxylin–eosin staining showed that DYY could reduce intestinal injury caused by sepsis. In addition, DYY can also inhibit inflammation, apoptosis, and promote cell proliferation in sepsis, and promote the expression of tight junction proteins.
Li Wang, Yuan‐Yuan Sha, Guan‐Yu Hu, Yi‐Ming Qian, Jian Guo   +4 more
wiley   +1 more source

Targeting opportunities presented by the pyrimidine biosynthesis pathway in Mycobacterium tuberculosis: a brief review. [PDF]

Biochem Soc Trans
Alberti M, Miggiano R.
europepmc   +1 more source