Advanced Science, Volume 13, Issue 19, 2 April 2026.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
Correction: LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions. [PDF]
OncotargetLiu F +10 more
europepmc +1 more source
“More” Artificial mRNAs: Beyond the Art of Nature
Advanced Science, Volume 13, Issue 20, 9 April 2026.Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui +3 more
wiley +1 more source
Anti-Toxoplasma activity of NBMPR is mediated through the inhibition of nucleoside and nucleobase transporters. [PDF]
Parasitol ResPan M +7 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 23, 23 April 2026.A new fluorescent probe, MitoQUMA, brings mitochondrial RNA G‐quadruplexes (mtRNA G4s) into view in live cells. This tool reveals that excessive mtRNA G4 formation halts mitochondrial RNA granule (MRG) assembly, opposite to the phase‐separation role of cytoplasmic RNA G4s. A chemical genetic screen further identifies a Wnt/β‐catenin–GRSF1–mtRNA G4 axis
Gui‐Xue Tang +7 more
wiley +1 more source
Increased brightness of fluorescent uridine, qU, inside single- and double-stranded RNA. [PDF]
Sci RepKarlsson AFE +5 more
europepmc +1 more source
Genomic Variants Associated With Oocyte and Embryo Production in Dairy Gir Cattle
Animal Genetics, Volume 57, Issue 2, April 2026.ABSTRACT The use of in vitro fertilization protocols associated with genomic selection increases genetic gain in dairy cattle. The aims of this study were to uncover genetic variants in a specific interval on BTA7 and to investigate their effects on the number of oocytes and embryos in dairy Gir.
Renata de Fatima Bretanha Rocha +6 more
wiley +1 more source
Upcycling Fermented Adlay Bran Ethanol Extract Residues Promotes Human Dermal Fibroblast Proliferation and Wound Healing. [PDF]
J Microbiol BiotechnolVan JY +8 more
europepmc +1 more source
Uridine diphosphate glucose and uridine diphosphate galactose in galactosemia
The Journal of Pediatrics, 1990 Michael J. Palmieri +3 more
openaire +1 more source
Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7‐associated Alzheimer's disease risk
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION ABCA7 (ATP binding cassette subfamily A member 7) encodes a lipid transporter associated with increasing risk for Alzheimer's disease (AD). A 44‐base pair deletion in ABCA7 (rs142076058; p.Arg578Alafs) is a strong risk factor in individuals of African ancestry (AA).
Younji Nam +23 more
wiley +1 more source