Results 151 to 160 of about 75,343 (258)

Structural and Functional Insights Into (S)‐5′‐C‐Guanidinopropyl Uridine‐Modified Oligonucleotides With 2′‐O‐Methyl and 2′‐Fluoro Substitutions for RNAi Therapeutics

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Novel (S)‐5′‐guanidinopropyl uridine analogs bearing 2′‐O‐methyl or 2′‐fluoro substitutions enhance nuclease resistance and mismatch discrimination while preserving A‐form RNA structure and potent RNAi activity. These modifications provide a promising strategy for improving the stability, specificity, and therapeutic potential of siRNA‐based medicines.
Sugahara Masaki, Elsayed M. Mahmoud, Shuichi Sakamoto, Yoshihito Ueno   +3 more
wiley   +1 more source

Episignature leads to diagnosis and reclassification of DYRK1A variant in a child with syndromic neurodevelopmental disorder: a case report. [PDF]

Front Genet
Al-Younis I, Basque L, Crapoulet N, Dyack S, Del Caño-Ochoa F, Ramón-Maiques S, MacKay SB, Rzasa J, Sadikovic B, McConkey H, Ben Amor M.   +10 more
europepmc   +1 more source

MANGO‐“Fruitcage”: A Conditional Photocage Utilizing a Fluorescence Light‐Up Aptamer

Advanced Optical Materials, Volume 14, Issue 29, 7 August 2026.
Fruitcaging ‐ a proof of concept study of a conditional photocage (Thiazol‐Orange) activated upon binding to the fluorescence light up aptamer (Mango). The prolongation of the excited state lifetime explains the redirection of the reactive pathway toward photocleavage and provides a sensitive spectroscopic readout.
Konstantinos Stamatakis, Nina Kaltenschnee, Francesco A. Greco, Marko Mitrović, Stefan Knapp, Alexander Heckel, Josef Wachtveitl   +6 more
wiley   +1 more source

Structural analysis of uridine modifications in solved RNA structures. [PDF]

NAR Genom Bioinform
Arteaga SJ, Znosko BM.
europepmc   +1 more source

Uridine diphosphate glucose and uridine diphosphate galactose in galactosemia

The Journal of Pediatrics, 1990
Michael J. Palmieri, Shirley Rogers, Gerard T. Berry, Stanton Segal   +3 more
openaire   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Targeted metabolomic profiling of gastric cancer biopsies. [PDF]

Indian J Med Res
Rangarajan A, Natarajan T, Lakshminarayanan S, Sundersingh S, Subramani J, Gopisetty G.   +5 more
europepmc   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2764-2776, August 2026.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Role of uridine phosphorylase 1 in cancer: A comprehensive pan-cancer analysis highlighting its prognostic and therapeutic potential. [PDF]

Medicine (Baltimore)
Yu S, Jiang T.
europepmc   +1 more source

A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2180-2191, August 2026.
Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm, Martin Pfeiffer, Johannes Zöhrer, Bernd Nidetzky   +3 more
wiley   +1 more source