Results 131 to 140 of about 75,343 (258)

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, EarlyView.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

Longitudinal dynamics of fasting plasma uridine in the preclinical stage of type 1 diabetes. [PDF]

J Endocr Soc
Xiong Q, Jang C, Wang K, Fu L, Ding L, Wang ZV, Wang P, Deng Y.   +7 more
europepmc   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

Uridine analogs prevent stress granule formation, not by blocking PKR recognition, but by inhibiting the synthesis of T7 RNA polymerase byproducts. [PDF]

RNA
Ihn SJ, Jiang E, Kejiou NS, Wang YE, Farlam-Williams L, Palazzo AF, Lee HO.   +6 more
europepmc   +1 more source

Thyroid antibody positivity in pregnancy is associated with altered reproductive hormone concentrations and placental growth in Lewis rats

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid antibody positivity (TAb+) in pregnancy is associated with adverse pregnancy outcomes, but the mechanisms are unclear. This study developed a rodent model of TAb+ in pregnancy, induced prior to mating so that TAb+ exposure occurred throughout the pregnancy. TAb+ did not alter thyroid hormone concentrations and had minimal
Rebecca L. Brady, Nykola L. Kent, Anna G. Reid, Liana P. Paszkowski, Ashley S. Meakin, Dayna A. Zimmerman, Dinithi T. Mahaliyanage, Elliott S. Neal, Michael D. Wiese, Helle Bielefeldt‐Ohmann, Janna L. Morrison, James S. M. Cuffe   +11 more
wiley   +1 more source

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas, Reyna Jones, Robert A. Parise, Pinakin Pandya, Christopher J. Bakkenist, Jan H. Beumer   +5 more
wiley   +1 more source

Uridine diphosphate glucuronosyltransferase 1A1 gene polymorphisms and treatment outcomes in HIV and MTB coinfection in sub-Saharan Africa: a scoping review protocol. [PDF]

BMJ Open
Vhanda D, Musarurwa C, Chikwati RP, Muziringa M, Dandara C, Manasa J, Chirenda J, Mavenyengwa RT.   +7 more
europepmc   +1 more source

Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen‐dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to assess its systemic exposure following topical administration.
Aylin Okutan, Oliver Krug, Gregor Fußhöller, Thomas Piper, Mario Thevis   +4 more
wiley   +1 more source

Correction: Uridine alleviates the aging of alveolar epithelial cells in idiopathic pulmonary fibrosis through the Keap1-Nrf2 signaling pathway. [PDF]

Sci Rep
Ding C, Zuo R, Liao Q, Guo Z, He J, Ye Z, Liu G.   +6 more
europepmc   +1 more source

Conjugated Linoleic Acid‐Enriched Fermented Dairy Modulates Microbiota and Metabolites to Alleviate MASLD: Insights From Multi‐Omics and Causal Mediation Analysis

Food Frontiers, Volume 7, Issue 5, September 2026.
In a 120‐day randomized trial, CLA‐enriched fermented dairy remodeled the gut microbiota and rewired host metabolic pathways in patients with MASLD. These changes were accompanied by reductions in ALT, total cholesterol, creatinine, and hs‐CRP, supporting a microbiota‐mediated dietary strategy for metabolic and liver health.
Fei Mi, Yanjiao Wang, Jia Xiong, Yiyuan Ma, Hongmei Pan, Jianzhong Yin, Yunmei Chai, Yao Wang, Xin Xu, Ai Zhang, Qingwen Ma, Hui Wang, Dongbai Liu, Shaoxiong Wu   +13 more
wiley   +1 more source