Results 141 to 150 of about 75,343 (258)

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Osmolality-Independent Impact of Sodium on Glycosylation of an Fc-Fusion Protein and the Hexosamine Biosynthesis Pathway in a Chinese Hamster Ovary Cell Line. [PDF]

Biotechnol J
Reiniger J, Pöttner A, Rosenberger L, Zimmer A.   +3 more
europepmc   +1 more source

Comparison Between Respiratory‐Triggered and Free‐Breathing Signal Acquisition Methods for Single‐Voxel Phosphorus Magnetic Resonance Spectroscopy of the Liver on a Clinical System

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 702-711, September 2026.
ABSTRACT Background The optimal protocol for clinical liver 31P‐magnetic resonance spectroscopy (MRS) remains unclear. Single‐voxel 31P‐MRS using image‐selected in vivo spectroscopy (ISIS) employs respiratory‐triggering (RT) or free‐breathing (FB) acquisition.
Kumi Ozaki, Jihun Kwon, Marc Van Cauteren, Yasutomo Katsumata, Yukichi Tanahashi, Satoshi Goshima   +5 more
wiley   +1 more source

Identification of TgENT1 as the TgUUT1 Uracil/Uridine Transporter of <i>Toxoplasma gondii</i>. [PDF]

Pathogens
Elati HAA, Ferreira Silva M, Sheiner L, de Koning HP.   +3 more
europepmc   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

Increasing Transfection of Human Monocyte-Derived Dendritic Cells by Optimizing Lipid Nanoparticle Ionizable Lipid and mRNA Uridine Modification. [PDF]

Pharmaceutics
Lambart I, Flender D, Liu D, Hong Hoang J, Hesse M, Campillo-Davo D, Lion E, Van Audenaerde J, Schiller S, Simon J, Geissler S, Smits E, Mäder K, Zaryouh H.   +13 more
europepmc   +1 more source

Differential Expression of Human and Bacterial Proteins Reveals Microbiome–Host Crosstalk in Metabolic Disorders

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT Purpose The growing prevalence of obesity, MetS, and T2DM highlights the need to better understand host–microbiota interactions. While gut microbiota has been widely investigated, interactions between the oral microbiota and human salivary proteins remain largely unexplored.
Carlos Vinicius Ferreira da Silva, Carlos José Ferreira da Silva, Fernanda da Silva Marinho, Youssef Bacila Sade, Sandra Mara Naressi Scapin, Fabiano L. Thompson, Cristiane Thompson, Eidy de Oliveira Santos   +7 more
wiley   +1 more source

CRISPR-Cas9-mediated targeted gene deletion in <i>Aspergillus calidoustus</i>, a non-model environmental mold. [PDF]

Microbiol Spectr
Hollomon JM, Dahlstrom KM.
europepmc   +1 more source

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients

Clinical Genetics, Volume 110, Issue 3, Page 379-388, September 2026.
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Camille Bergès, Clément Sauvestre, Sophie Naudion, Catherine Vincent Delorme, Thomas Smol, Mélanie Rama, Stephanie Moortgat, Isabelle Maystadt, Rogier Kersseboom, Martina Wilke, Tahsin Stefan Barakat, Yoann Vial, Laurence Perrin, Sandrine Passemard, Farooq Ahmad, Muhammad Umair, Tobias Haack, Mona Grimmel, Alma Kuechler, Anne Slavotinek, Patrick Devine, Ugur Hodoglugil, Faisal Zafar, Erum Afzal, Tracy Dudding‐Byth, Guillaume Jouret, Lucas Herissant, Stephanie Efthymiou, Henry Houlden, Marine Legendre, Vincent Michaud   +30 more
wiley   +1 more source

Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport. [PDF]

Nat Metab
Curtabbi A, Jaroszewicz SN, Sanz-Cortés R, Acín-Pérez R, Prymidis D, Cherevatenko M, Martínez-de-Mena R, Esteban-Amo MJ, de la Fuente MA, Frezza C, Enríquez JA.   +10 more
europepmc   +1 more source