Results 171 to 180 of about 74,197 (237)

Nutritional Intervention With Perennial Ryegrass Modulates UA Metabolism in Goslings via Gut Microbiota–Antioxidant Pathway Modulation

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Perennial ryegrass supplementation modulates UA‐metabolism in goslings by reducing serum uric acid and creatinine through inhibition of hepatic xanthine oxidase and upregulation of urate transporters (ABCG2, OAT1, OAT3). It enhances antioxidant capacity via Nrf2 activation, improves intestinal barrier integrity, and enriches beneficial gut microbiota ...
Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Saira Saif, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi   +8 more
wiley   +1 more source

Fractionation of Oligosaccharide Nucleoside Mixtures by Single Pass Nano-Diafiltration. [PDF]

Eng Life Sci
Thiele U, Kaloghlian T, Wohlgemuth J, Brenner-Weiß G, Tschöpe A, Franzreb M, Bleher K.   +6 more
europepmc   +1 more source

Hepatotoxicity Associated with Labetalol Use: A Case Report with Systematic Review and Disproportionality Analysis Using FAERS

The Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.
Abstract Labetalol is widely prescribed as a first‐line antihypertensive in pregnancy; however, rare but potentially severe idiosyncratic hepatotoxicity has been reported, with a disproportionately strong reporting signal for liver injury relative to other β‐blockers.
Emma D. Hendriksen, Michael Rieder, Elizabeth Urbantke   +2 more
wiley   +1 more source

Liver Metabolomic Profiling Reveals Distinct Signatures Between Steatosis and Metabolic Dysfunction-Associated Steatohepatitis. [PDF]

Liver Int
Palomurto S, Flam E, Kaminska D, Virtanen KA, Kärjä V, Käkelä P, Pajukanta P, Eberlé D, Haas JT, Raverdy V, Caiazzo R, Pattou F, Staels B, Pihlajamäki J, Männistö V.   +14 more
europepmc   +1 more source

Mini‐Catalytically Inactive Cas13X‐Derived RNA Base Editing of β‐Catenin Attenuates Pulmonary Damage in a Murine Acute Lung Injury Model

MedComm, Volume 7, Issue 4, April 2026.
AAV6.2FF‐delivered CARTEL (mini‐dCas13X‐mediated A‐to‐I editor) introduces c.121A>G editing in β‐catenin RNA of alveolar type II cells, leading to sustained Wnt/β‐catenin activation, robust AT2 proliferation, significant attenuation of LPS‐induced acute lung injury, and no excess off‐target edits or fibrotic toxicity for 4 weeks.
Wenyi Liu, Wanda Bi, Saiying Hou, Juan Du, Ling Zeng, Anqiang Zhang, Huacai Zhang, Dalin Wen, Qingli Cai, Chu Gao, Ping Lin, Min Wu, Li Li, Jianxin Jiang   +13 more
wiley   +1 more source

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters. [PDF]

Sci Adv
Lang M, Renard S, El-Meouche I, Amoura A, Denamur E, Hardy L, Bos J, Brosschot T, Ingersoll MA, Bacqué E, Mazel D, Baharoglu Z.   +11 more
europepmc   +1 more source

Identification of Blood Pressure‐Associated Metabolites by Integrating Metabolomic and Genetic Analysis

MedComm, Volume 7, Issue 4, April 2026.
This study identified 10 potential causality between metabolites and blood pressure and found potential genetic regulators of two metabolites. Multiomics integration revealed that a genetic variant near the omega‐3 metabolism genes (FADS1/FADS2) may influence blood pressure regulation by modulating prostaglandin E3 levels.
Yuanjiao Liu, Chunxiao Cheng, Xiong‐Fei Pan, Wei Shao, Dan Zhou, Yimin Zhu   +5 more
wiley   +1 more source

Trehalose-mediated reshaping of the rhizosphere microbiome drives tea root rot progression. [PDF]

Front Microbiol
Zhu Q, Chen B, Hu W, Huang Y, Wang S, Feng M, Zhao J, Yu M, Li M, Gong X.   +9 more
europepmc   +1 more source

Bacterial Cellulose Synthase Catalyzes the Formation of Chitin

ChemistrySelect, Volume 11, Issue 15, 20 April 2026.
Recombinant BcsA‐B from Rhodobacter sphaeroides is shown to cleave UDP‐GlcNAc (uridine diphosphate N‐acetylglucosamine), generating chitin with distinct β‐chitin Raman bands. These findings reveal that a cellulose synthase can process an alternative nucleotide sugar, providing biochemical evidence for the co‐synthesis of cellulose and chitin.
Neraz Shai, Sapir Korman Shadmi, Mariela J. Pavan, Filipe Natalio   +3 more
wiley   +1 more source

AI‐Augmented Iterative Screening of Libraries Against RNA Targets (AISLAR) Boosts Discovery of SAR‐Tractable RNA Binders and Rational Analog Design

Small Science, Volume 6, Issue 4, April 2026.
AI‐augmented iterative screening of libraries against RNA targets (AISLAR) combines fluorescence resonance energy transfer screening, machine learning, and validation by dose response and isothermal titration calorimetry to discover RNA binders. Applied to p53 mRNA motifs, AISLAR identified chemotypes with tractable structure–activity relationships ...
Haruhiko Hattori, Maina Otsu, Koji Imai, Mebuki Narahara, Jiro Kondo, Amiu Shino, Ella Czarina Morishita   +6 more
wiley   +1 more source