Results 271 to 280 of about 134,815 (339)

Precision‐Engineered Poly(GMA‐EGDMA) Microspheres for Multifunctional Applications

Particle &Particle Systems Characterization, Volume 43, Issue 1, January 2026.
The study presents multifunctional poly(GMA‐EGDMA) microspheres designed for advanced separation, catalysis, and biomedical engineering. Through precision synthesis and surface engineering, these microspheres exhibit excellent stability, tunable porosity, and high reactivity.
Imran Ali, Shakeel Ahmad Khan, Mujeeb ur Rahman, Abdul Wasy Zia   +3 more
wiley   +1 more source

Uridine-Cytidine Kinase 2 (UCK2)/Uridine-Cytidine Kinase Like 1 (UCKL1) complex exacerbates the differentiation of myocardial fibroblasts via TRIM21/Smurf2/Smad3 pathway after myocardial infarction. [PDF]

Mol Biomed
Zhou X, Zhang Y, Wang H, Qi Z, Gu Z, Cui J, Hu Z, Wang Y.   +7 more
europepmc   +1 more source

Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability‐Limited Multicompartment Liver Model

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
Obesity, MASH and Statins: Insights from a PBPK/PD Zonal Liver Model. ABSTRACT Statins are frequently prescribed for hyperlipidemia, a common comorbidity in patients with obesity and/or metabolic dysfunction‐associated steatohepatitis (MASH). However, limited knowledge exists on how MASH may alter statin disposition within hepatocytes where the statin ...
William A. Murphy, Noora Sjöstedt, Mailys De Sousa Mendes, Mattie Hartauer, Kim L. R. Brouwer, Sibylle Neuhoff   +5 more
wiley   +1 more source

Development of 3D-Printed Gel-Based Supplement-Containing Tablets with Tailored Release Profiles for Neurological Pain Management. [PDF]

Pharmaceutics
Kazlauskaite JA, Matulyte I, Bernatoniene J.   +2 more
europepmc   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Exploring transcriptome plasticity at the intersection of cell signaling, metabolism and computational biology. [PDF]

Exp Mol Med
Yong J.
europepmc   +1 more source

Triplet RNA Lipid Nanoparticles for Locoregional Cancer Immunotherapy

Small Science, Volume 6, Issue 1, January 2026.
LNPs deliver the immunoadjuvant pIpC into tumors to activate local cells. After activation, additional RNA (siRNA or mRNA) can modulate immune pathways by suppressing immunoinhibitory targets or inducing immunostimulatory ones. This coordinated “triplet RNA” approach may enhance immune activation within the tumor microenvironment.
Adam A. Walters, Yue Qin, Amer F. Saleh, Calvin C. L. Cheung, Qingyang Lyu, Ziyi Zhu, Hiba A. M. Gafar, Julie Tzu‐Wen Wang, Khuloud T. Al‐Jamal   +8 more
wiley   +1 more source

1,2,4-Triazole-Based First-in-Class Non-Nucleoside Inhibitors of the Bacterial Enzyme MraY. [PDF]

ACS Bio Med Chem Au
Berida T, Huang TY, Weck SC, Lutz M, McKee SR, Kagerah N, Manning DL, Jahan ME, Mishra S, Herrmann J, Müller R, Doerksen RJ, Stallings CL, Ducho C, Roy S.   +14 more
europepmc   +1 more source

Nanozyme‐Integrated 3D‐Printed Gradient Scaffold Rescues Redox Homeostasis for Enhanced Osteochondral Repair

Small Structures, Volume 7, Issue 1, January 2026.
This work presents a novel 3D‐printed gradient scaffold for osteochondral repair. The implant features distinct layers, each designed for a specific therapeutic role: a cartilage layer protects tissue and a bone layer promotes regeneration. In vivo experiments confirm the scaffold's effectiveness, demonstrating its dual ability to maintain chondrocyte ...
Chuan Hu, Dingqi Xie, Jianyi Li, Yang Jin, Jiechao Xia, Gu Jin, Lin Ye, Zhijun Hu   +7 more
wiley   +1 more source

Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer. [PDF]

Cancer Res
Gebru MT, Hoffman TE, Boudreau A, Vu N, Han F, Wang P, Folk E, Wu X, Newton J, Foster-Duke KD, Gajda J, Villa S, Yang N, Sandoval CM, Grant C, Wildeboer SE, Buck WR, Hickson JA, Firestone AJ, Kort M, Bennett BD, Shotwell JB, Wilson NS, Stokoe D.   +23 more
europepmc   +1 more source