Results 271 to 280 of about 99,858 (332)

Exploring the untapped potential of single‐cell and spatial omics in plant biology

New Phytologist, Volume 247, Issue 3, Page 1098-1116, August 2025.
Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The field of plant biology has widely adopted single‐cell transcriptome and chromatin accessibility profiling and spatial transcriptomics, which extend ...
Tatsuya Nobori
wiley   +1 more source

A Pilot Metabolomic Study for Diagnosing <i>Aspergillus</i> Infection in Immunocompromised Pediatric Cancer Patients. [PDF]

Int J Mol Sci
Abdelmoneim TK, Ramzy A, Zaki MA, Karam A, Hesham A, Osama A, Sabar N, Mokhtar M, Youssef NA, Ahmed EA, Shalaby L, Salama A, Kamel A, Elenany M, Magdeldin S.   +14 more
europepmc   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, Volume 75, Issue 4, Page 282-307, July/August 2025.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Light‐Triggered CRISPR/Cas12a for Genomic Editing and Tumor Regression

Angewandte Chemie, Volume 137, Issue 28, July 7, 2025.
A photo‐triggered CRISPR/Cas12a machinery for gene editing is introduced. The machinery is applied for endogenous DNA methyltransferase 1 (DNMT1) gene editing and for in vitro disruption of the hepatocyte growth factor (HGF) gene. The machinery is used for in vivo knockout and disruption of the HGF gene in HepG2 tumors, resulting in effective apoptosis
Hong Liu, Jiantong Dong, Renzhi Wu, Jun Dai, Xiaoding Lou, Fan Xia, Itamar Willner, Fujian Huang   +7 more
wiley   +2 more sources

How Binding Site Flexibility Promotes RNA Scanning by TbRGG2 RRM: A Molecular Dynamics Simulation Study. [PDF]

J Chem Inf Model
Lemmens T, Šponer J, Krepl M.
europepmc   +1 more source

HR‐MS Analysis of the Covalent Binding of Edaravone to 5‐Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5‐Formylcytidine Residue

Rapid Communications in Mass Spectrometry, Volume 39, Issue 14, 30 July 2025.
ABSTRACT Rationale Edaravone (EDA) is a radical scavenger and an antioxidant drug approved to treat amyotrophic lateral sclerosis and used as a research tool to explore treatment of neurodegenerative diseases and cancers. It is also a reactive agent, known as PMP (1‐phenyl‐3‐methyl‐5‐pyrazolone), used for the analysis of polysaccharides composition ...
Romain Regnault, Mostafa Kouach, Laurence Goossens, Xavier Thuru, Christian Bailly, Jean‐François Goossens   +5 more
wiley   +1 more source

Trafficking of the telomerase RNA using a novel genetic approach. [PDF]

PLoS One
Day JK, Palmero BJ, Allred AL, Li J, Hooda FB, Witte G, Dejneka AM, Sandler AM, Kirk KE.   +8 more
europepmc   +1 more source

Vibrational Partition Functions from Bond Order and Populations Relationships

ChemPhysChem, Volume 26, Issue 14, July 18, 2025.
A new computational model is presented that predicts vibrational partition functions using bond orders and populations relationships (QBOP). This model demonstrates that thermochemical energy contributions can be reasonably approximated based on well‐conditioned orbital populations without the need for a costly Hessian calculation.
Barbaro Zulueta, John A. Keith
wiley   +1 more source

Mechanism of Inhibition of the Active Triphosphate Form of 2'-α-Fluoro,2'-β-bromouridine against Yellow Fever Virus RNA-Dependent RNA Polymerase. [PDF]

ACS Infect Dis
Gordon CJ, Walker SM, LeCher JC, Amblard F, Schinazi RF, Götte M.   +5 more
europepmc   +1 more source

Efficient generation of uridine/uracil auxotrophic mutants in homokaryotic <i>Cordyceps militaris</i> strains for constructing a food-grade expression platform. [PDF]

Mycoscience
Trinh MT, Bui KT, Thai HD, Nguyen TD, Nguyen GTH, Ha KT, Nguyen HT, Le DA, Pham HTT, Nguyen SV, Vu TX, Tran VT.   +11 more
europepmc   +1 more source