Results 301 to 310 of about 99,858 (332)

Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.

Journal of Medicinal Chemistry, 2019
We report the synthesis and biological evaluation of a series of 4'-fluoro-2'- C-substituted uridines. Triphosphates of the uridine analogues exhibited a potent inhibition of hepatitis C virus (HCV) NS5B polymerase with IC50 values as low as 27 nM. In an
Guangyi Wang, N. Dyatkina, M. Prhavc, C. Williams, V. Serebryany, Yujian Hu, Yongfei Huang, Jinqiao Wan, Xiangyang Wu, J. Deval, Amy D. Fung, Zhinan Jin, Hua Tan, K. Shaw, Hyunsoon Kang, Qingling Zhang, Yuen Tam, A. Stoycheva, A. Jekle, D. Smith, L. Beigelman   +20 more
semanticscholar   +1 more source

Uridyl Transferases and the Formation of Uridine Triphosphate: Enzymic Production of Uridine Triphosphate: Uridine Diphosphoglucose Pyrophosphorolysis

Nature, 1953
Uridyl Transferases and the Formation of Uridine Triphosphate: Enzymic Production of Uridine Triphosphate: Uridine Diphosphoglucose ...
Enrico Cutolo, Evelyn E. B. Smith, Herman M. Kalckar, Agnete Munch-Petersen   +3 more
openaire   +3 more sources

Uridine dynamic administration affects circadian variations in lipid metabolisms in the liver of high-fat-diet-fed mice

Chronobiology International, 2019
Carbohydrate and lipid metabolism in the liver has been reported to follow a certain circadian rhythm. Moreover, uridine supplementation also affected glucose and lipid homeostasis in previous studies; however, the mechanisms remain unclear.
Yi-lin Liu, Yumei Zhang, J. Yin, Z. Ruan, Xin Wu, Yulong Yin   +5 more
semanticscholar   +1 more source

Biochemistry of uridine in plasma

Clinica Chimica Acta, 2011
Uridine is a pyrimidine nucleoside that plays a crucial role in synthesis of RNA, glycogen, and biomembrane. In humans, uridine is present in plasma in considerably higher quantities than other purine and pyrimidine nucleosides, thus it may be utilized for endogenous pyrimidine synthesis.
Tetsuya Yamamoto, Yuji Moriwaki, Zenta Tsutsumi, Masafumi Kurajoh, Hidenori Koyama, Takuhito Shoji   +5 more
openaire   +3 more sources

Uridine Kinase: Altered Enzyme with Decreased Affinities for Uridine and CTP

Archives of Biochemistry and Biophysics, 1998
Uridine kinase is the rate-limiting enzyme in the salvage pathway for uridine or cytidine of mammalian cells. Alignment of the uridine kinase sequence with other nucleoside and nucleotide kinases supports a common ancestor for all of these. Three polypeptide segments for the ATP site and three polypeptide segments for the acceptor nucleoside site have ...
Thomas W. Traut, Patricia A. Ropp
openaire   +3 more sources

ChemInform Abstract: BENZOYLAMINATION OF URIDINE DERIVATIVES

Chemischer Informationsdienst, 1976
AbstractAlternativ zu der sonst üblichen vielstufigen Synthese wird eine Methode zur Darstellung von Acylaminonucleosiden beschrieben.
Susumu Takizawa, Hiroo Morimato, Oyo Mitsunobu   +2 more
openaire   +4 more sources

Feedback onhibition of uridine kinase by cytidine triphosphate and uridine triphosphate

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1964
Abstract Uridine kinase was found to be the rate-limiting step in the anabolism of uridine to its successive nucleotide derivatives. This enzymatic activity was susceptible to feedback inhibition by the pyrimidine nucleoside triphosphate end-products; effective inhibition was exerted by UTP and even more strikingly by CTP.
E.P. Anderson, E.P. Anderson, R.W. Brockman, R.W. Brockman   +3 more
openaire   +3 more sources

NMR Studies on the Self-Association of Uridine and Uridine Analogues

Chemistry - A European Journal, 1998
Association constants for the dimerization of acylated uridine and two analogues, 4-thiouridine and 6-oxadihy- drouridine, have been determined in chloroform solution. At 293 K, self-as- sociation constants K were found to decrease in the order uridine> 6- oxadihydrouridine> 4-thiouridine.
Klaus Weisz, Anita Dunger, Hans-Heinrich Limbach   +2 more
openaire   +2 more sources

Neuronal uridine metabolism

Acta Neurologica Scandinavica, 1992
Uridine and other nucleic acids form part of RNA, DNA, coenzymes, second messengers, etc. Uridine uptake in nerve cells is an expression of neuronal RNA synthesis. More knowledge of uridine functions in neurones may give a better understanding of mechanisms underlying dementia, and they could be useful in treating brain tumors.
openaire   +3 more sources

A dizinc complex for selective fluorescence sensing of uridine and uridine-containing dinucleotides

Chemical Communications, 2007
A dizinc complex with a polyamine macrocycle is able to selectively bind and sense uridine (U) as well as the uridine-containing ribodinucleotides U(3'-5')pU and U(3'-5')pA, thanks to an exciplex emission arising from a pi-stacked complex involving the dipyridine unit and Zn(II)-bound uridine moieties.
Barbara Valtancoli, Laura Bussotti, Andrea Lapini, Silvia Biagini, Carla Bazzicalupi, Andrea Bencini, Emanuela Berni, Paolo Foggi, Paolo Foggi, Agnese Marcelli, Claudia Giorgi, Enrico Faggi   +11 more
openaire   +6 more sources