Results 71 to 80 of about 98,911 (236)

Uridine Prevents Negative Effects of OXPHOS Xenobiotics on Dopaminergic Neuronal Differentiation

open access: yesCells, 2019
Neuronal differentiation appears to be dependent on oxidative phosphorylation capacity. Several drugs inhibit oxidative phosphorylation and might be detrimental for neuronal differentiation.
Eldris Iglesias   +8 more
doaj   +1 more source

Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update

open access: yesBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2002
Uridine, a pyrimidine nucleoside essential for the synthesis of RNA and bio-membranes, is a crucial element in the regulation of normal physiological processes as well as pathological states. The biological effects of uridine have been associated with the regulation of the cardio-circulatory system, at the reproduction level, with both peripheral and ...
Deliang Cao   +5 more
openaire   +3 more sources

Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae

open access: yesPLoS ONE, 2015
In eukaryotes, wobble uridines in the anticodons of tRNALys UUU, tRNAGlu UUC and tRNAGln UUG are modified to 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm5s2U).
Roland Klassen   +5 more
semanticscholar   +1 more source

Detection of RNA nucleoside modifications with the uridine-specific ribonuclease MC1 from Momordica charantia

open access: yesRNA: A publication of the RNA Society, 2015
A codon-optimized recombinant ribonuclease, MC1 is characterized for its uridine-specific cleavage ability to map nucleoside modifications in RNA. The published MC1 amino acid sequence, as noted in a previous study, was used as a template to construct a ...
Balasubrahmanym Addepalli   +2 more
semanticscholar   +1 more source

The nucleoside uridine isolated in the gas phase.

open access: yesAngewandte Chemie, 2015
Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques.
I. Peña, C. Cabezas, J. Alonso
semanticscholar   +1 more source

The predictive value of plasma uridine for type 2 diabetes and its atherosclerotic complications

open access: yesEndocrine Connections
Objective: Uridine might be a common link between pathological pathways in diabetes and cardiovascular diseases. This study aimed to investigate the predictive value of plasma uridine for type 2 diabetes (T2D) and T2D with atherosclerosis.
Yueyuan Yang   +3 more
doaj   +1 more source

Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism

open access: yesPLoS ONE, 2015
Neurodegenerative diseases are linked to neuronal cell death and impairment of neurite outgrowth. An edible mushroom, Pleurotus giganteus was found to stimulate neurite outgrowth in vitro but the chemical constituents and the underlying mechanism is yet ...
C. Phan   +4 more
semanticscholar   +1 more source

Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: a drug-target Mendelian randomization study

open access: yesFrontiers in Pharmacology
BackgroundThe relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors and prostate cancer is still unknown. Although these inhibitors can influence tumor glycolysis, the underlying mechanism requires further exploration.MethodsA two-sample
Yilong Lin   +10 more
doaj   +1 more source

Uridine release during aminopyridine-induced epilepsy

open access: yesNeurobiology of Disease, 2004
Uridine, like adenosine, is released under sustained depolarization and it can inhibit hippocampal neuronal activity, suggesting that uridine may be released during seizures and can be involved in epileptic mechanisms.In an in vivo microdialysis study ...
A Slézia   +8 more
doaj  

Uridine alleviates high-carbohydrate diet-induced metabolic syndromes by activating sirt1/AMPK signaling pathway and promoting glycogen synthesis in Nile tilapia (Oreochromis niloticus)

open access: yesAnimal Nutrition, 2023
Carbohydrates have a protein sparing effect, but long-term feeding of a high-carbohydrate diet (HCD) leads to metabolic disorders due to the limited utilization efficiency of carbohydrates in fish.
Nan-Nan Zhou   +8 more
doaj  

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