Results 81 to 90 of about 98,911 (236)
The Mechanism of Action of Uridine Diphosphoglucose Dehydrogenase
Journal of Biological Chemistry, 1971 Abstract Uridine diphospho-α-d-galacto-hexodialdose (UDP-Gal-6-CHO) and uridine diphospho-α-d-gluco-hexodialdose (UDP-Glc-6-CHO) were produced from UDP-galactose through the use of galactose oxidase and UDP-glucose 4-epimerase. UDP-Glc-6-CHO was shown to be an intermediate in the reaction catalyzed by the enzyme UDP-glucose dehydrogenase, indicating ...
S. Kirkwood, Gary L. Nelsestuen
openaire +3 more sources
5-fluorouracil Toxicity Mechanism Determination in Human Keratinocytes: in vitro Study on HaCaT
Prague Medical Report, 2018 5-fluorouracil (5-FU) and capecitabine therapy is often accompanied by palmar-plantar erythrodysesthesia (PPE) which is manifestation of 5-FU toxicity in keratinocytes. The main mechanisms of 5-FU action are thymidylate synthase (TS) inhibition which can
Jan Hartinger +5 more
doaj +1 more source
Uridine prevents tamoxifen-induced liver lipid droplet accumulation
BMC Pharmacology and Toxicology, 2014 BackgroundTamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease.
Thuc T. Le, Y. Urasaki, G. Pizzorno
semanticscholar +1 more source
The Isolation of Uridine-5'-Triphosphate from Muscle. [PDF]
, 1954 Rolf Bergkvist +3 more
openalex +1 more source
Respiratory Research, 2014 RationalePulmonary fibrosis is a progressive disease with only few treatment options available at the moment. Recently, the nucleoside uridine has been shown to exert anti-inflammatory effects in different animal models, e.g.
S. Cicko +8 more
semanticscholar +1 more source
Bioelectronic Medicine, 2019 Background Glutamatergic neurons represent the largest neuronal class in the brain and are responsible for the bulk of excitatory synaptic transmission and plasticity. Abnormalities in glutamatergic neurons are linked to several brain disorders and their
Eric H. Chang +3 more
doaj +1 more source
Uridine diphosphoglucose dehydrogenase of pea seedlings [PDF]
, 1957 Jack L. Strominger, L. W. Mapson
openalex +1 more source
Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand
Molecules, 2014 In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands.
Lijun Song +6 more
doaj +1 more source
Uridine Prevents Fenofibrate-Induced Fatty Liver
PLoS ONE, 2014 Uridine, a pyrimidine nucleoside, can modulate liver lipid metabolism although its specific acting targets have not been identified. Using mice with fenofibrate-induced fatty liver as a model system, the effects of uridine on liver lipid metabolism are ...
Thuc T. Le, Y. Urasaki, G. Pizzorno
semanticscholar +1 more source
Uridine diphosphoglucose pyrophosphorylase of pea seeds [PDF]
, 1958 Donella H. Turner, John F. Turner
openalex +1 more source