Results 71 to 80 of about 75,343 (258)

Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease

Frontiers in Immunology
IntroductionInflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology.
Caiyi Yuan, Qiang Wang, Yuying Chen, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Yang Dai, Hongxia Bai   +10 more
doaj   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Dietary uridine improves lipid homeostasis in high-fat diet-induced obese mice by regulating liver gene expression and metabolomic profiles

Frontiers in Nutrition
IntroductionObesity is caused by excessive storage of adipose tissue and leads to metabolic disorders. Uridine exerts modulatory effects on lipid metabolism, but the regulatory mechanism in obesity needs further research.MethodsIn this study, the effects
Yilin Liu, Huihui Zhang, Huihui Zhang, Xudong Yang, Chunyan Xie   +4 more
doaj   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model

Future Science OA
Aims To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin—administered alone and in combination—in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & Methods Oral doses of ...
Esam Y. Qnais, Muna Barakat, Rabaa Y. Athamneh, Mohammad A. A. Al-Najjar, Lujain F. Alzaghari, Dinesh Kumar Chellappan, Abdelrahim Alqudah   +6 more
doaj   +1 more source

Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation[S]

Journal of Lipid Research, 2013
We report in this study an intrinsic link between pyrimidine metabolism and liver lipid accumulation utilizing a uridine phosphorylase 1 transgenic mouse model UPase1-TG.
Thuc T. Le, Amy Ziemba, Yasuyo Urasaki, Eugene Hayes, Steven Brotman, Giuseppe Pizzorno   +5 more
doaj   +1 more source

Controllable engineered probiotic microspheres for treating ulcerative colitis: A cascade enzyme‐catalyzed strategy to restore intestinal redox homeostasis

BMEMat, EarlyView.
A dual strategy integrating genetic engineering and physical encapsulation was proposed to enhance the cell viability and antioxidant properties of probiotics. The cascade antioxidant enzymes released from probiotic microspheres restore intestinal redox homeostasis by eliminating intestinal reactive oxygen species for ulcerative colitis treatment ...
Xiaolong Mao, Xiangwei Lv, Miaomiao Zhang, Jiayi Liu, Yun Chen, Yunna Li, Gaoyuan Liu, Fuming Yang, Ziqiang Han, Yunyun Wei   +9 more
wiley   +1 more source

An Electrophilic Uridine Building Block for Post‐Synthetic RNA Modification as Exemplified for Spin Labeling

Chemistry – A European Journal, EarlyView.
An electrophilic 5‐isothiocyanatomethyl uridine building block enables modular post‐synthetic RNA labeling with primary amine‐containing probes. Positioning the functionality in the major groove minimizes structural perturbation and allows facile conjugation of sensitive tags such as TEMPO spin labels for paramagnetic relaxation enhancement studies ...
Lisa Ruetz, Sonja Leiner, Alessandro Marotto, Raphael Plangger, Christoph Kreutz   +4 more
wiley   +1 more source

Control of Gemcitabine Activity With Blue and Red Light

Chemistry – A European Journal, EarlyView.
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten, Konstantin L. Stock, Marius Hyprath, Hannah Weisser, Timo Weinrich, Dieter Steinhilber, Alexander Heckel   +6 more
wiley   +1 more source