The Journal of Clinical Pharmacology, Volume 65, Issue 7, Page 805-814, July 2025.Abstract Obesity significantly influences drug pharmacokinetics (PK), which challenges optimal dosing. This study examines the effects of diet‐and‐exercise‐induced weight loss on key drug‐metabolizing enzymes and gastric emptying in patients with obesity, who frequently require medications for comorbidities.
Shuhan Liu +8 more
wiley +1 more source
Cell-Free Multi-Enzyme Synthesis and Purification of Uridine Diphosphate Galactose. [PDF]
Chembiochem, 2022 Mahour R +8 more
europepmc +1 more source
Transforming Niclosamide through Nanotechnology: A Promising Approach for Long COVID Management
Small, Volume 21, Issue 27, July 10, 2025.This review highlights the transformation of niclosamide, a repurposed drug, through molecular science strategies to overcome its pharmacokinetic limitations. Emphasizing novel nanohybrid technologies and delivery platforms, the article explores their therapeutic potential in targeting the complex pathophysiology of long COVID, paving the way for ...
Sanoj Rejinold N +3 more
wiley +1 more source
mBioMultidrug-resistant bacteria such as the opportunistic pathogen Pseudomonas aeruginosa, which causes life-threatening infections especially in immunocompromised individuals and cystic fibrosis patients, pose an increasing threat to public health.
Larissa Dirr +9 more
doaj +1 more source
Effect of the genetic mutant G71R in uridine diphosphate-glucuronosyltransferase 1A1 on the conjugation of bilirubin. [PDF]
Open Life Sci, 2022 Chen H, Zhong D, Gao Z, Wu X.
europepmc +1 more source
Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections
Small Science, Volume 5, Issue 7, July 2025.This review critically evaluates fluorescent antibiotics as promising agents combining diagnostic precision with therapeutic efficacy. It highlights advances in probe design, chemical conjugation strategies, real‐time imaging applications, selective pathogen detection, and targeted therapy. The potential to combat antimicrobial resistance is discussed,
Tan Phuoc Ton +3 more
wiley +1 more source
The Genetics of Glucose-6-Phosphate-Dehydrogenase (G6PD) and Uridine Diphosphate Glucuronosyl Transferase 1A1 (UGT1A1) Promoter Gene Polymorphism in Relation to Quantitative Biochemical G6PD Activity Measurement and Neonatal Hyperbilirubinemia. [PDF]
Children (Basel), 2023 Riskin A +7 more
europepmc +1 more source
5'-terminal structure of poliovirus polyribosomal RNA is pUp [PDF]
, 1976 Poliovirus RNA purified from virus-specific polyribosomes does not contain m7G in a 5'-5'-pyrophosphate linkage at its 5'-end. The only potential 5'-end found in ribonuclease digests of this RNA is pUp, which is present in a yield of 1 mole/mole of ...
Baltimore, David +2 more
core
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Crop JournalCrop yield depends on biomass, which is primarily associated with photosynthesis. We previously demonstrated that two photorespiratory bypasses, i.e., GOC (glycolate oxidase + oxalate oxidase + catalase) and GCGT (glycolate oxidase + catalase ...
Bodi Li +7 more
doaj